4.6 Article

Pulmonary Daoyin as a traditional Chinese medicine rehabilitation programme for patients with IPF: A randomized controlled trial

期刊

RESPIROLOGY
卷 26, 期 4, 页码 360-369

出版社

WILEY
DOI: 10.1111/resp.13972

关键词

6‐ min walking distance; Daoyin; idiopathic pulmonary fibrosis; pulmonary rehabilitation; traditional Chinese medicine

资金

  1. Program for Research Project for Practice Development of National TCM Clinical Research Bases [JDZX2015158]
  2. Doctoral Fund of Henan College of TCM, China [BSJJ2015-27]
  3. Special Program of National TCM Clinical Research Bases of Traditional Chinese Medicine Administration of Henan Province, China [2018JDZX007]

向作者/读者索取更多资源

The PD program showed better 6MWD results in IPF patients compared to the exercise and control groups. It is safe and effective, serving as a rehabilitation intervention to increase exercise tolerance and a suitable alternative for PR.
Background and objective IPF is a chronic progressive lung disease in which PR provides benefit for patients. PD, a TCM PR programme, has known effectiveness in COPD, but its utility in IPF is unknown. We investigated its effectiveness and safety in patients with IPF. Methods A 6-month randomized controlled trial (RCT) was conducted in three Chinese clinics. Ninety-six participants diagnosed with IPF were randomly assigned to one of the three groups: the PD group received a PD programme two times a day, 5 days/week for 2 months, and the exercise group exercised via a stationary cycle ergometer, 30 min/day, 5 days/week for 2 months. Volunteers in the control group were advised to maintain their usual activities. Primary outcomes were changes from baseline in the 6MWD and HRQoL score on the SGRQ-I at 1 and 2 months (at the end of the intervention) and at 6 months (4 months after the intervention). Secondary outcomes measures included FVC, DLCO (% predicted) and the changes in mMRC. Results The 6MWD was increased in the PD group compared to exercise and control groups. 6MWD increased by 60.44 m in the PD group, 32.16 m in the exercise group and 12.42 m in controls after the 2 months of rehabilitation programme. The between-group differences in the change from baseline were 28.78 m (95% CI: 0.54 to 56.01; P = 0.044) and 48.02 m (95% CI: 23.04 to 73.00; P < 0.001) at 2 months, and 25.61 m (95% CI: -0.67 to 51.89; P = 0.058) and 50.93 m (95% CI: 25.47 to 76.40; P < 0.001) at 6 months, respectively, including a difference exceeding the MCID. There was no significant change in the SGRQ-I score, the mMRC dyspnoea score, FVC and DLCO (% predicted) in either the PD or exercise groups. Conclusion Two months after the intervention, a clinically meaningful difference in 6MWD was observed favouring the PD programme. The PD programme is safe and effective as a rehabilitation intervention designed to increase exercise tolerance and is an appropriate substitute for PR.

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