期刊
ANDROLOGIA
卷 53, 期 1, 页码 -出版社
WILEY
DOI: 10.1111/and.13888
关键词
heat shock protein 90; male infertility; semen; single nucleotide polymorphisms; spermatozoa
类别
资金
- National Natural Science Foundation of China [81801525]
- Natural Science Foundation of Zhejiang Province [LY17H040002, LQ17H040004]
- Special Project for the Research Institutions of Zhejiang Province [C11920D-04]
- Zhejiang Provincial Program for the Cultivation of High-Level Innovative Health Talents
- Sci&Tech Program Project of Zhejiang Province [2018C37126]
- Health Sci&Tech Plan Project of Zhejiang Province [2019KY363, 2018KY039]
This study found an association between the rs11547523 SNP in the HSP90AA1 gene and idiopathic male infertility in the Chinese population. However, the specific pathogenic mechanism of this SNP remains unclear, necessitating further research.
The association of single nucleotide polymorphisms (SNPs) in heat shock protein 90 (HSP90) genes with idiopathic male infertility remains unclear. In this study, the five selected SNPs in HSP90AA1 namely rs10133307, rs10873531, rs11547523, rs11621560 and rs7145597 were genotyped in 116 idiopathic infertile males and 185 ethnically matched fertile males using the Sequenom MassARRAY assay. The role of these SNPs in male infertility was then studied using multiple genetic models. We observed that genotype distribution (p = .028) and allelic frequency (p = .032) of rs11547523 were significantly different between the infertile and fertile groups. In particular, A genotype of rs11547523 was associated with an increased risk of infertility in the allele (OR = 2.508, p = .048), dominant (OR = 2.733, p = .030) and additive models (OR = 0.366, p = .031). However, there were no significant differences in semen parameters including seminal volume (p = .452), sperm concentration (p = .727), total sperm number (p = .588), motility (p = .282) and morphology (p = .975) between A and A/G genotypes of rs11547523. These results indicate that rs11547523 in HSP90AA1 may be associated with idiopathic male infertility in the Chinese population. The outcome of this study contributes to the development of the diagnosis of male infertility.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据