期刊
CORTEX
卷 67, 期 -, 页码 95-105出版社
ELSEVIER MASSON, CORPORATION OFFICE
DOI: 10.1016/j.cortex.2015.03.021
关键词
Environmental sounds; Music; Musicophilia; Reward; Affect; Alzheimer's disease; Frontotemporal dementia; Semantic dementia; Progressive aphasia; VBM
资金
- Alzheimer's Research UK
- Brain Research Trust
- Wolfson Foundation
- Wellcome Trust
- UK Medical Research Council
- NIHR Queen Square Dementia Biomedical Research Unit [CBRC 161]
- AVID Radiopharamaceuticals
- National Brain Appeal - Frontotemporal Dementia Research Fund
- MRC Research Training Fellowship [MR/J011274/1]
- Alzheimer Research UK PhD Fellowship [ART-PhD2011-10]
- Wellcome Trust Senior Clinical Fellowship [091673/Z/10/Z]
- MRC [MR/J011274/1, MR/M008525/1] Funding Source: UKRI
- Medical Research Council [MR/M008525/1, MR/J011274/1] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0512-10033, CL-2012-18-010] Funding Source: researchfish
Patients with dementia may exhibit abnormally altered liking for environmental sounds and music but such altered auditory hedonic responses have not been studied systematically. Here we addressed this issue in a cohort of 73 patients representing major canonical dementia syndromes (behavioural variant frontotemporal dementia (bvFTD), semantic dementia (SD), progressive nonfluent aphasia (PNFA) amnestic Alzheimer's disease (AD)) using a semi-structured caregiver behavioural questionnaire and voxel-based morphometry (VBM) of patients' brain MR images. Behavioural responses signalling abnormal aversion to environmental sounds, aversion to music or heightened pleasure in music ('musicophilia') occurred in around half of the cohort but showed clear syndromic and genetic segregation, occurring in most patients with bvFTD but infrequently in PNFA and more commonly in association with MAPT than C9orf72 mutations. Aversion to sounds was the exclusive auditory phenotype in AD whereas more complex phenotypes including musicophilia were common in bvFTD and SD. Auditory hedonic alterations correlated with grey matter loss in a common, distributed, right-lateralised network including anteromesial temporal lobe, insula, anterior cingulate and nucleus accumbens. Our findings suggest that abnormalities of auditory hedonic processing are a significant issue in common dementias. Sounds may constitute a novel probe of brain mechanisms for emotional salience coding that are targeted by neurodegenerative disease. (C) 2015 The Authors. Published by Elsevier Ltd.
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