Copper(II)-Catalysed Aerobic Oxidative Coupling of Arylamines with Hexafluoroisopropanol: An Alternative Methodology for Constructing Fluorinated Compounds

The selective functionalisation of arylamine derivatives with hexafluoroisopropanol through copper(II)-catalysed aerobic oxidative coupling was developed to generate various fluoroalkylated arylamines under mild conditions. This method has a wide substrate scope with excellent functional group tolerance and provides the fluorinated products in good to excellent yields. Furthermore, preliminary studies indicate that this reaction occur via a radical mechanism. This protocol, which uses atmospheric O-2 as an oxidant, provides an alternative green route for constructing fluorinated compounds.

Automated summary

A new method for generating fluoroalkylated arylamines under mild conditions with a wide substrate scope and excellent yields was developed using copper(II)-catalysed aerobic oxidative coupling. Preliminary studies suggest the reaction occurs via a radical mechanism, and the protocol offers an alternative green route for constructing fluorinated compounds by using atmospheric O2 as an oxidant.