期刊
PURINERGIC SIGNALLING
卷 17, 期 1, 页码 49-54出版社
SPRINGER
DOI: 10.1007/s11302-020-09748-5
关键词
Pain; Spinal dorsal horn; Neuropathic pain; Primary afferents
资金
- Canadian Institutes of Health Research
- Krembil Foundation
- Ontario Ministry of Health and Long-Term Care
Purinergic signaling plays important roles in somatosensory and nociceptive transmission in the dorsal horn of the spinal cord, mediating both physiological and pathological pain processing. Additionally, there is evidence of sexual dimorphism in the involvement of purinergic signaling in pain, with P2X4 receptors being implicated in pain hypersensitivity primarily in males.
Purinergic signalling plays important roles in somatosensory and nociceptive transmission in the dorsal horn of the spinal cord under physiological and pathophysiological conditions. Physiologically, ATP mediates excitatory postsynaptic responses in nociceptive transmission in the superficial dorsal horn, and in transmission of innocuous primary afferent inputs in the deep dorsal horn. Additionally, extracellular conversion of ATP to adenosine mediates inhibitory postsynaptic responses from Pacinian corpuscle afferents, and is implicated in analgesia caused by transcutaneous electrical nerve stimulation in humans. In terms of pathological pain, P2X4 receptors de novo expressed on dorsal horn microglia are implicated in pain hypersensitivity following peripheral nerve injury. There is evidence that involvement of such P2X4 receptors is sexually dimorphic, occurring in males but not in females. Thus, the roles of purinergic signalling in physiological and pathological pain processing are complex and remain an ever-expanding field of research.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据