期刊
SYNTHESIS-STUTTGART
卷 53, 期 5, 页码 785-804出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0040-1705965
关键词
enyne metathesis; dienynes; one-pot; ruthenium catalysis; natural products; ring-closing; cascade; domino reactions; biologically active
资金
- Ministero dell'Istruzione, dell'Universita e della Ricerca (MIUR) (Italian Ministry of Education, University and Research) [20157WW5EH]
Enyne metathesis reactions are powerful tools for the preparation of a wide range of synthetic and natural chemical substances with increasing efficiency and environmental sustainability. By forming a stable conjugated system through the reaction, cascade reaction sequences can be designed to synthesize multiple ring compounds in a one-pot fashion. The correlation between synthetic organic chemistry and medicinal chemistry has led to notable approaches for the synthesis of biologically relevant compounds via enyne metathesis-based one-pot processes.
Enyne metathesis reactions are powerful tools for the preparation of a wide range of synthetic and natural chemical substances with increasing efficiency and environmental sustainability. The driving force of the reaction is the formation of a stable conjugated system, i.e., a diene, which through further functionalization steps can be used for the construction of skeletally complex molecular architectures. These concepts are exploited to design cascade reaction sequences, where multiple rings can be formed in a one-pot fashion by combining metathetic protocols with various chemical transformations. The strong correlation between synthetic organic chemistry and medicinal chemistry prompted us to review the most notable approaches for the synthesis of biologically relevant compounds via enyne metathesis-based one-pot processes. With the aim to provide a modern and practical overview, by taking into consideration the scientific literature on this topic, we have focused the majority of our attention on the research performed in the last decade. This review covers the literature from 2003 to 2020.
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