Whole genome sequencing to decipher the virulence phenotype of hypervirulent Klebsiella pneumoniae responsible for liver abscess, Marseille, France

We described three clinical cases of pyogenic liver abscess caused by hypervirulent Klebsiella pneumoniae (hvKp) successfully treated by prolonged antibiotherapy, in which one case was complicated by endophthalmitis. Whole genome sequencing helped to confirm the diagnosis of these hvKp strains, which belong to clonal complexes CC86 and CC23 and carried hvKp-associated genes (magA and/or rmpA). This syndrome is increasingly reported in France and Europe and raises questions about the source of infection.

Automated summary

Pyogenic liver abscess caused by hypervirulent Klebsiella pneumoniae is increasingly reported in France and Europe. Whole genome sequencing confirms the diagnosis of these hypervirulent strains. Prolonged antibiotic therapy is necessary for successful treatment.