期刊
BRAIN IMAGING AND BEHAVIOR
卷 15, 期 4, 页码 1876-1885出版社
SPRINGER
DOI: 10.1007/s11682-020-00381-9
关键词
fMRI; Global signal; Functional connectivity; Adolescent-onset schizophrenia
类别
资金
- Natural Science Foundation of China [61533006, u1808204, 61806042, 61673089] Funding Source: Medline
- Sichuan Science and Technology Program [2018TJPT0016] Funding Source: Medline
- Department of Science and Technology of Sichuan Province (CN) [2019YJ0180] Funding Source: Medline
- National Key Project of Research and Development of Ministry of Science and Technology [2018AAA0100705] Funding Source: Medline
Adolescent-onset schizophrenia (AOS) patients show frequency-specific changes in the global signal (GS) affecting the default mode network and sensory regions, with a stronger driving effect in the 0.01-0.1 Hz frequency band, and significant frequency-by-group interaction observed in the frontoparietal network.
Adolescent-onset schizophrenia (AOS) is a severe neuropsychiatric disease associated with frequency-specific abnormalities across distributed neural systems in a slow rhythm. Recently, functional magnetic resonance imaging (fMRI) studies have determined that the global signal. (GS) is an important source of the local neuronal activity in 0.01-0.1 Hz frequency band. However, it remains unknown whether the effects follow a specific spatially preferential pattern in different frequency bands in schizophrenia. To address this issue, resting-state fMRI data from 39 drug-naive AOS patients and 31 healthy controls (HCs) were used to assess the changes in GS topography patterns in the slow-4 (0.027-0.073 Hz) and slow-5 bands (0.01-0.027 Hz). Results revealed that GS mainly affects the default mode network (DMN) in slow-4 and sensory regions in the slow-5 band respectively, and GS has a stronger driving effect in the slow-5 band. Moreover, significant frequency-by-group interaction was observed in the frontoparietal network. Compared with HCs, patients with AOS exhibited altered GS topography mainly located in the DMN. Our findings demonstrated that the influence of the GS on brain networks altered in a frequency-specific way in schizophrenia.
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