期刊
CORTEX
卷 63, 期 -, 页码 79-89出版社
ELSEVIER MASSON, CORPORATION OFFICE
DOI: 10.1016/j.cortex.2014.07.007
关键词
Language; Transmitter receptors; Brain mapping; Human cerebral cortex
资金
- European FET flagship project Human Brain Project
- Portfolio Theme Supercomputing and Modeling for the Human Brain of the Helmholtz Association, Germany
- Doctoral Program of the Max Planck Institute for Human Cognitive and Brain Sciences
The language network is a well-defined large-scale neural network of anatomically and functionally interacting cortical areas. The successful language process requires the transmission of information between these areas. Since neurotransmitter receptors are key molecules of information processing, we hypothesized that cortical areas which are part of the same functional language network may show highly similar multireceptor expression pattern (receptor fingerprint), whereas those that are not part of this network should have different fingerprints. Here we demonstrate that the relation between the densities of 15 different excitatory, inhibitory and modulatory receptors in eight language-related areas are highly similar and differ considerably from those of 18 other brain regions not directly involved in language processing. Thus, the fingerprints of all cortical areas underlying a large-scale cognitive domain such as language is a characteristic, functionally relevant feature of this network and an important prerequisite for the underlying neuronal processes of language functions. (C) 2014 Elsevier Ltd. This is an open access article under the CC BY-NC-ND license
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