期刊
CELLULOSE
卷 28, 期 2, 页码 871-879出版社
SPRINGER
DOI: 10.1007/s10570-020-03550-7
关键词
Cellulose nanocrystal; Hydroxyapatite; Biomedical materials; Tissue engineering materials; Dental materials; Sustainable development goals (SDGs)
资金
- JSPS KAKENHI [JP18H01717]
- cooperative research program of Network Joint Research Center for Materials and Devices
In this study, a core-shell structured composite of cellulose nanocrystal (CNC) and hydroxyapatite (HAp) (CNC@HAp) was successfully synthesized via a simple aqueous neutralization titration method. The method allows for easy control of the coating amounts of HAps and the resulting CNC@HAp pellets exhibit high mechanical strength, making them suitable for tissue engineering and medical purposes. The process and product of the study are environmentally-friendly, non-toxic, simple, and pure, demonstrating the potential for easy application in various fields.
Exploring the simple fabrication process to prepare CNC@HAp for biological tissues is still a challenging subject considering the wide applications of the composites for bio tissues. In this work, aiming for the fabrication of CNC@HAp composites via a simple and environment-friendly process and materials, we propose the neutralization titration in the presence of CNCs in the suspension. Core-shell structured composite of cellulose nanocrystal (CNC) and hydroxyapatite (HAp) (CNC@HAp) was successfully synthesized via simple aqueous neutralization titration. The method studied successfully hybridizes CNCs with a certain amount of HAps and easily controls the coating amounts of HAps from 9 wt% to 17 wt%. In particular, CNC@HAp pellets were easily prepared by simple compression molding from the powder of hybridized CNCs and HAps and the pellets showed high mechanical strength of over 500 N with a low strain of less than 5%. Both the process and the product of the study were environmental-friendly, no toxicity, simple and pure therefore the CNC@HAp can be easily applied to tissue engineering and medical purposes.
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