期刊
THERANOSTICS
卷 11, 期 3, 页码 1016-1030出版社
IVYSPRING INT PUBL
DOI: 10.7150/thno.51777
关键词
Tumor-associated macrophage; tumor microenvironment; metabolism; tumor immunotherapy
资金
- National Natural Science Foundation of China [81620108023, 81821003, 81925030, 82003018]
- China Postdoctoral Science Foundation [2018M643861]
- Talent Training Program of Army Military Medical University [2018XLC2015]
The article discusses the metabolic regulation between TME and TAMs. Immune molecules from TAMs and TME act as mediators of signal transduction. TAMs are influenced by metabolites produced in the TME.
Macrophages phagocytize pathogens to initiate innate immunity and products from the tumor microenvironment (TME) to mediate tumor immunity. The loss of tumor-associated macrophage (TAM)-mediated immune responses results in immune suppression. To reverse this immune disorder, the regulatory mechanism of TAMs in the TME needs to be clarified. Immune molecules (cytokines and chemokines) from TAMs and the TME have been widely accepted as mutual mediators of signal transduction in the past few decades. Recently, researchers have tried to seek the intrinsic mechanism of TAM phenotypic and functional changes through metabolic connections. Numerous metabolites derived from the TME have been identified that induce the cell-cell crosstalk with TAMs. The bulk tumor cells, immune cells, and stromal cells produce metabolites in the TME that are involved in the metabolic regulation of TAMs. Meanwhile, some products from TAMs regulate the biological functions of the tumor as well. Here, we review the recent reports demonstrating the metabolic regulation between TME and TAMs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据