期刊
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
卷 13, 期 1, 页码 8-22出版社
KOREAN ACAD ASTHMA ALLERGY & CLINICAL IMMUNOLOGY
DOI: 10.4168/aair.2021.13.1.8
关键词
Eosinophils; nasal polyps; sinusitis; biologics; inflammation
资金
- National Institute of Allergy and Infectious Disease [U19 AI136443, K23 AI141694, P01 AI145818]
Chronic rhinosinusitis (CRS) is a complex medical condition characterized by chronic innate and adaptive mucosal inflammation, often treated with corticosteroids and sinus surgery, but newer biologics have been evaluated as alternatives. Studies suggest that a prominent feature in CRS is type 2 inflammation, including tissue eosinophilia.
Chronic rhinosinusitis (CRS) with or without nasal polyposis is a complex medical condition characterized by varying patterns of chronic innate and adaptive mucosal inflammation. Treatment of CRS has been traditionally limited to corticosteroids and sinus surgery; however, novel biologics have more recently been evaluated as steroid- and surgery-sparing options. While it is clear that there are different subtypes or endotypes of CRS, perhaps the most frequent presentation involves the features of type 2 inflammation, including a prominent tissue eosinophilia component. The purpose of this review is to provide an update on eosinophil biology as well as on the potential contribution of eosinophils and their mediators to the pathophysiology of CRS, drawing mechanistic conclusions mainly from studies of human sinus mucosal tissues, nasal secretions, and benefits (or lack thereof from the use of various pharmacotherapies. The unavoidable conclusion derived from this approach is that eosinophils themselves cannot fully explain the underlying pathophysiology of this complex disorder.
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