Concise Total Synthesis of Curvulone B

A concise and convergent stereoselective synthesis of curvulone B is described. The synthesis utilized a tandem isomerization followed by C-O and C-C bond-forming reactions following Mukaiyama-type aldol conditions for the construction of the trans-2,6-disubstituted dihydropyran ring system as the key steps. Other important features of this synthesis are a cross-metathesis, epimerization, and Friedel-Crafts acylation.

Automated summary

A concise and stereoselective synthesis of Curvulone B was achieved through utilizing tandem isomerization and C-O/C-C bond-forming reactions under Mukaiyama-type aldol conditions. Other key features of this synthesis include cross-metathesis, epimerization, and Friedel-Crafts acylation.