期刊
NEURAL REGENERATION RESEARCH
卷 16, 期 4, 页码 757-764出版社
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/1673-5374.295349
关键词
Alzheimer's disease; brain; central nervous system; factor; in vivo; model; pathways; protein; rat
资金
- National Natural Science Foundation of China [81370462]
- Climbing Scholars Support Plan of Liaoning Province of China
- Principal's Fund of Liaoning Medical University of China [20140107]
- Natural Science Foundation of Liaoning Province of China [20180551185]
Melatonin administration alleviated learning and memory impairments, improved microvessel morphology in the cerebral cortex and hippocampus, increased microvessel density, alleviated pathological injuries of cerebral neurons, and decreased the expression of vascular endothelial growth factor and its receptors in a rat model of Alzheimer's disease. This suggests that melatonin may improve cognitive function in Alzheimer's disease by ameliorating cerebral microvascular abnormalities.
Melatonin can attenuate cardiac microvascular ischemia/reperfusion injury, but it remains unclear whether melatonin can also ameliorate cerebral microvascular abnormalities. Rat models of Alzheimer's disease were established by six intracerebroventricular injections of amyloid-beta 1-42, administered once every other day. Melatonin (30 mg/kg) was intraperitoneally administered for 13 successive days, with the first dose given 24 hours prior to the first administration of amyloid-beta 1-42. Melatonin ameliorated learning and memory impairments in the Morris water maze test, improved the morphology of microvessels in the cerebral cortex and hippocampus, increased microvessel density, alleviated pathological injuries of cerebral neurons, and decreased the expression of vascular endothelial growth factor and vascular endothelial growth factor receptors 1 and 2. These findings suggest that melatonin can improve microvessel abnormalities in the cerebral cortex and hippocampus by lowering the expression of vascular endothelial growth factor and its receptors, thereby improving the cognitive function of patients with Alzheimer's disease. This study was approved by the Animal Care and Use Committee of Jinzhou Medical University, China (approval No. 2019015) on December 6, 2018.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据