Pharmacological aspects of fisetin

Over the past decades, epidemiological studies have concluded that a diet rich in plant-derived products plays a pivotal role in human health. Fisetin (3,3',4',7-tetrahydroxyflavone) is a hydrophobic polyphenolic compound primarily found in edible plants (e.g. strawberry, blueberry, apple, grape, persimmon, kiwi, and cucumber). Various preclinical studies have revealed that fisetin exhibits a wide range of pharmacological effects such as antioxidant, anti-inflammatory, anti-carcinogenic, anti-osteoporotic, antimicrobial, and anti-diabetic properties. Therefore, the pharmacological in vitro and in vivo studies on fisetin are discussed in this review. Additionally, this review would be useful for further study regarding the potential of natural products, notably fisetin, and its therapeutic potential for the prevention and treatment of diseases.

Automated summary

Plant-derived products rich diet plays a crucial role in human health, with fisetin being a hydrophobic polyphenolic compound found primarily in edible plants. Fisetin exhibits various pharmacological effects such as antioxidant, anti-inflammatory, and anti-carcinogenic properties, making it a promising candidate for further research on the prevention and treatment of diseases.