期刊
JOURNAL OF CANCER
卷 12, 期 2, 页码 451-459出版社
IVYSPRING INT PUBL
DOI: 10.7150/jca.48587
关键词
Head and Neck Cancer; Hypothyroidism; Radiotherapy
类别
资金
- National Natural Science Foundation of China [81672971]
Hypothyroidism after radiotherapy in head and neck cancer patients is influenced by factors such as radiation dose, treatment technique, thyroid volume, gender, and age. Incidence increases over time and a prospective large sample study is recommended for modeling complications related to radiation-induced hypothyroidism.
This paper reviews the factors related to hypothyroidism after radiotherapy in patients with head and neck cancer to facilitate the prevention of radiation-induced hypothyroidism and reduce its incidence. Hypothyroidism is a common complication after radiotherapy in patients with head and neck cancer, wherein the higher the radiation dose to the thyroid and pituitary gland, the higher the incidence of hypothyroidism. With prolonged follow-up time, the incidence of hypothyroidism gradually increases. Intensity modulated radiotherapy should limit the dose to the thyroid, which would reduce the incidence of hypothyroidism. In addition, the risk factors for hypothyroidism include small thyroid volume size, female sex, and previous neck surgery. The incidence of radiation-induced hypothyroidism in head and neck cancer is related to the radiation dose, radiotherapy technique, thyroid volume, sex, and age. A prospective, large sample and long-term follow-up study should be carried out to establish a model of normal tissue complications that are likely to be related to radiation-induced hypothyroidism.
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