期刊
ONCOLOGY LETTERS
卷 21, 期 1, 页码 -出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2020.12288
关键词
fatty acids synthase; free fatty acids; invasive ductal carcinoma; breast cancer cells; metastasis
类别
资金
- Sichuan Provincial Science and Technology Department [2016JY143]
Fatty acid metabolism is closely related to tumor occurrence and development, with specific fatty acids influencing the activity and migration of tumor cells. Five specific fatty acids may serve as potential tumor markers in invasive ductal carcinoma (IDC), and the expression level of fatty acid synthase (FASN) affects the serum fatty acid profiles of IDC patients. Additionally, FASN-mediated changes in specific fatty acids promote tumor cell migration.
Fatty acid metabolism is closely associated with the occurrence and development of tumors. The aim of the present study was to investigate whether the key enzyme involved in fatty acid synthesis, fatty acid synthase (FASN), mediates fatty acid changes that affect the activity and migration of breast cancer cells, and whether specific fatty acids play a role in tumor metastasis. The difference in serum fatty acid profiles between patients with invasive ductal carcinoma (IDC) and healthy controls was evaluated by gas chromatography-mass spectrometry (GC-MS) fatty acid profile analysis, and it was revealed that five types of fatty acids may be potential tumor markers in IDC. Immunohistochemistry and GC-MS analysis revealed that FASN expression affected the serum fatty acid profiles of patients with IDC. Following FASN knockdown, the migration of SK-Br-3 breast cancer cells was inhibited, and the contents of various fatty acids both inside and outside the cell decreased, while the contents of various fatty acids inside and outside the cell increased following FASN overexpression. The results of the present study revealed that the expression level of FASN affected the content of fatty acids in IDC tissues and breast cancer cell lines, and that FASN-mediated changes in specific fatty acids promoted tumor cell migration.
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