期刊
CORTEX
卷 62, 期 -, 页码 41-55出版社
ELSEVIER MASSON, CORP OFF
DOI: 10.1016/j.cortex.2014.07.015
关键词
Planum temporale; Asymmetry; Genome-wide association scan; Sexual dimorphism; Steroid hormones
资金
- Biobanking and Biomolecular Resources Research Infrastructure (Netherlands) (BBMRI-NL)
- Hersenstichting Nederland
- Netherlands Organisation for Scientific Research (NWO)
- German Federal Ministry of Education and Research
- German Ministry of Cultural Affairs
- Social Ministry of the Federal State of Mecklenburg-West Pomerania [01ZZ9603, 01ZZ0103, 01ZZ0403]
- Federal Ministry of Education and Research [03IS2061A, 03ZIK012]
- Siemens Healthcare, Erlangen, Germany
- Federal State of Mecklenburg West Pomerania
The genetic determinants of cerebral asymmetries are unknown. Sex differences in asymmetry of the planum temporale (PT), that overlaps Wernicke's classical language area, have been inconsistently reported. Meta-analysis of previous studies has suggested that publication bias established this sex difference in the literature. Using probabilistic definitions of cortical regions we screened over the cerebral cortex for sexual dimorphisms of asymmetry in 2337 healthy subjects, and found the PT to show the strongest sex-linked asymmetry of all regions, which was supported by two further datasets, and also by analysis with the FreeSurfer package that performs automated parcellation of cerebral cortical regions. We performed a genome-wide association scan (GWAS) meta-analysis of PT asymmetry in a pooled sample of 3095 subjects, followed by a candidate-driven approach which measured a significant enrichment of association in genes of the 'steroid hormone receptor activity' and 'steroid metabolic process' pathways. Variants in the genes and pathways identified may affect the role of the PT in language cognition. (C) 2014 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据