4.6 Article

Ascorbic acid accelerates Wallerian degeneration after peripheral nerve injury

期刊

NEURAL REGENERATION RESEARCH
卷 16, 期 6, 页码 1078-1085

出版社

WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/1673-5374.300459

关键词

ascorbic acid; axon; macrophage; myelin; peripheral nerve injury; phagocytosis; Schwann cell; Wallerian degeneration

资金

  1. National Natural Science Foundation of China [81870982, 81571182]
  2. Program for Changjiang Scholars and Innovative Research Team in Universities of China [IRT-16R37]
  3. National Key Basic Research Program of China [2014CB542202]
  4. Science and Technology Project of Guangdong Province of China [2015A020212024]
  5. Key Research & Development Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory of China [2018GZR110104008]
  6. Natural Science Foundation of Guangdong Province of China [2017A030312009]
  7. Research Grant of Guangdong Province Key Laboratory of Psychiatric Disorders of China [N201904]

向作者/读者索取更多资源

Ascorbic acid accelerates Wallerian degeneration by promoting the degradation of axons and myelin in injured nerves, inducing Schwann cell dedifferentiation, and enhancing macrophage recruitment and phagocytosis.
Wallerian degeneration occurs after peripheral nerve injury and provides a beneficial microenvironment for nerve regeneration. Our previous study demonstrated that ascorbic acid promotes peripheral nerve regeneration, possibly through promoting Schwann cell proliferation and phagocytosis and enhancing macrophage proliferation, migration, and phagocytosis. Because Schwann cells and macrophages are the main cells involved in Wallerian degeneration, we speculated that ascorbic acid may accelerate this degenerative process. To test this hypothesis, 400 mg/kg ascorbic acid was administered intragastrically immediately after sciatic nerve transection, and 200 mg/kg ascorbic acid was then administered intragastrically every day. In addition, rat sciatic nerve explants were treated with 200 mu M ascorbic acid. Ascorbic acid significantly accelerated the degradation of myelin basic protein-positive myelin and neurofilament 200-positive axons in both the transected nerves and nerve explants. Furthermore, ascorbic acid inhibited myelin-associated glycoprotein expression, increased c-Jun expression in Schwann cells, and increased both the number of macrophages and the amount of myelin fragments in the macrophages. These findings suggest that ascorbic acid accelerates Wallerian degeneration by accelerating the degeneration of axons and myelin in the injured nerve, promoting the dedifferentiation of Schwann cells, and enhancing macrophage recruitment and phagocytosis.

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