期刊
MOLECULAR MEDICINE REPORTS
卷 23, 期 1, 页码 -出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/mmr.2020.11671
关键词
bronchopulmonary dysplasia; apoptosis; endoplasmic reticulum stress; serine/threonine-protein kinase/endoribonuclease inositol-requiring enzyme 1 alpha; X-box binding protein 1; c-Jun N-terminal kinase; lung
资金
- National Natural Science Foundation of china [81571479]
BPD is the most common chronic lung disease in premature infants, characterized by alveolar dysplasia and pulmonary vascular development disorders. Endoplasmic reticulum stress-associated apoptosis, particularly through the IRE1 alpha pathway, plays a significant role in the development of BPD.
Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease in premature infants, and alveolar dysplasia and pulmonary vascular development disorders are the predominant pathological features. Apoptosis of lung epithelial cells is a key factor in the pathological process of alveolar developmental arrest. Endoplasmic reticulum stress (ERS)-associated apoptosis is a noncanonical apoptotic pathway involved in the development of several pulmonary diseases. Previous studies have demonstrated that protein kinase RNA-like endoplasmic reticulum kinase, inositol-requiring enzyme 1 alpha (IRE1 alpha) and activating transcription factor 6 can initiate the apoptosis signaling pathway mediated by ERS and induce apoptosis of injured cells. Among them, the IRE1 alpha pathway is the most conservative pathway in the unfolded protein response, which serves an important role in a number of pathological environments, to the extent of determining cell fate; however, it is rarely reported in BPD. Based on the establishment of a rat BPD model, the present study verified the activation of ERS in BPD and further confirmed that prolonged ERS inhibited the protective pathway, IRE1 alpha/X-box binding proteins, and activated the proapoptotic pathway, IRE1 alpha/c-Jun N-terminal kinase, to induce the apoptosis of lung epitheliums.
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