期刊
STEM CELL REVIEWS AND REPORTS
卷 17, 期 4, 页码 1154-1173出版社
SPRINGER
DOI: 10.1007/s12015-020-10090-x
关键词
Retinal regeneration; cell replacement therapy; exosomes; mitochondrial transfer; anti-inflammatory molecules
资金
- Ministry of Human Resource Development (MHRD)
- Indian Institute of Technology Guwahati (IITG)
Mesenchymal Stem Cells (MSCs) have therapeutic potential for repairing and restoring damaged retinal cells through their ability to differentiate into multiple lineages and secrete factors that prevent degeneration and improve function in the retina.
Mesenchymal Stem Cells (MSCs) have been studied extensively for the treatment of several retinal diseases. The therapeutic potential of MSCs lies in its ability to differentiate into multiple lineages and secretome enriched with immunomodulatory, anti-angiogenic and neurotrophic factors. Several studies have reported the role of MSCs in repair and regeneration of the damaged retina where the secreted factors from MSCs prevent retinal degeneration, improve retinal morphology and function. MSCs also donate mitochondria to rescue the function of retinal cells and exosomes secreted by MSCs were found to have anti-apoptotic and anti-inflammatory effects. Based on several promising results obtained from the preclinical studies, several clinical trials were initiated to explore the potential advantages of MSCs for the treatment of retinal diseases. This review summarizes the various properties of MSCs that help to repair and restore the damaged retinal cells and its potential for the treatment of retinal degenerative diseases.
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