期刊
PEDIATRIC INFECTIOUS DISEASE JOURNAL
卷 40, 期 1, 页码 E12-E17出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/INF.0000000000002965
关键词
common human coronavirus; viral surveillance; acute respiratory infections; young children; Jordan
资金
- UBS Optimus Foundation
- CTSA award from the National Center for Advancing Translational Sciences [UL1TR000445]
- NCATS, CTSA Program [5UL1TR002243-03, R54218]
Human coronaviruses (HCoVs) were detected in around 7% of hospitalized children in Amman, Jordan, with symptoms mainly being respiratory and fever. The detection peaked in winter-spring seasons, with a high frequency of viral codetection. Evaluation of the actual burden and pathogenic role of HCoVs in acute respiratory illness among children is needed.
Background: Human coronaviruses (HCoVs) are a significant cause of acute respiratory illness (ARI) in children; however, the role of HCoVs in ARI among hospitalized children in the Middle East is not well defined. Methods: Children under 2 years admitted with fever and/or respiratory symptoms were enrolled from 2010 to 2013 in Amman, Jordan. Nasal/throat swabs were collected and stored for testing. Demographic and clinical characteristics were collected through parent/guardian interviews and medical chart abstractions. Prior stored specimens were tested for HCoVs (HKUI, OC43, 229E and NL63) by qRT-PCR. Results: Of the 3168 children enrolled, 6.7% were HCoVs-positive. Among HCoV-positive children, the median age was 3.8 (1.9 -8.4) months, 59% were male, 14% were premature. 11% had underlying medical conditions and 76% had viral-codetection. The most common presenting symptoms were cough, fever, wheezing and shortness of breath. HCoVs were detected year-round, peaking in winter-spring months. Overall, 56%, 22%, 13% and 6% were 0C43, NL63, HKU1 and 229E, respectively. There was no difference in disease severity between the species, except higher intensive care unit admission frequency in NL63-positive subjects. Conclusions: HCoVs were detected in around 7% of children enrolled in our study. Despite HCoV detection in children with ARI with highest peaks in respiratory seasons. the actual burden and pathogenic role of HCoVs in ARI merits further evaluation given the high frequency of viral codetection.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据