4.0 Article

Experimental comparison of four nonlinear magnetic detection methods and considerations on clinical usability

期刊

出版社

IOP PUBLISHING LTD
DOI: 10.1088/2057-1976/abce90

关键词

magnetic nanoparticles; SPIONs; magnetic detection; nonlinear; clinical usability

资金

  1. Netherlands Organization for Scientific Research (NWO-TTW), under the research program Magnetic Sensing for Laparoscopy (MagLap) [14 322]

向作者/读者索取更多资源

Superparamagnetic iron oxide nanoparticles (SPIONs) exhibit a nonlinear magnetic response in clinical applications, making them less sensitive to the human body and surgical steel instruments. Among the four nonlinear magnetic detection methods compared, second harmonic detection shows the best SNR and potential for improvement.
Superparamagnetic iron oxide nanoparticles (SPIONs) are promising for clinical applications, because they have a characteristic nonlinear magnetic response when an external magnetic field is applied. This nonlinearity enables the distinct detection of SPIONs and makes measurements less sensitive to the human body and surgical steel instruments. In clinical applications, only a limited field strength for the magnetic detection is allowed. The signal to noise ratios (SNRs) of four nonlinear magnetic detection methods are compared. These methods include differential magnetometry and three variations of magnetic particle spectroscopy: frequency mixing, second harmonic detection and third harmonic detection. All methods were implemented on the same hardware and experimentally compared for various field strengths. To make the comparison fair, the same power was supplied to the excitation coil each time. In general, the SNR increases with increasing field strength. The SNR per drive field of all methods stabilizes or even decreases for field strengths above 6 mT. The second harmonic detection has the best SNR and the most room for improvement.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.0
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据