期刊
MOLECULAR & CELLULAR ONCOLOGY
卷 8, 期 1, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/23723556.2020.1837582
关键词
SAG; APC/C; UBE2C; UBE2S; cell cycle
类别
资金
- National Key R&D Program of China [2016YFA0501800]
CRL and APC/C, two RING-finger-type E3 ligases, regulate the cell cycle through negative crosstalk, ensuring the orderly progression of the cell cycle.
CRL and APC/C belong to the RING-finger-type E3 ligases, and both play important roles in cell cycle regulation. Recently, we found that SAG, a RING component of CRL, acts as an endogenous inhibitor of APC/C by competing with APC2 for E2s binding; while APC/C-CDH1 targets SAG for ubiquitylation and degradation at G1 phase. The negative crosstalk between these two E3s ensures the orderly cell cycle progression.
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