期刊
GASTROENTEROLOGY
卷 152, 期 2, 页码 340-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.gastro.2016.09.047
关键词
Crohn's Disease; Ulcerative Colitis; Dilation; Treatment
资金
- National Institutes of Health [T32DK083251, P30DK097948, 1K08DK110415, 5RO1DK050984]
- European Crohn's and Colitis Foundation
- Swiss National Science Foundation
- Swiss IBD Cohort Study [3347CO-108792]
In the last 10 years, we have learned much about the pathogenesis, diagnosis, and management of intestinal fibrosis in patients with inflammatory bowel diseases. Just a decade ago, intestinal strictures were considered to be an inevitable consequence of long-term inflammation in patients who did not respond to anti-inflammatory therapies. Inflammatory bowel diseasesLassociated fibrosis was seen as an irreversible process that frequently led to intestinal obstructions requiring surgical intervention. This paradigm has changed rapidly, due to the antifibrotic approaches that may become available. We review the mechanisms and diagnosis of this serious complication of inflammatory bowel diseases, as well as factors that predict its progression and management strategies.
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