期刊
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
卷 18, 期 3, 页码 727-735出版社
IVYSPRING INT PUBL
DOI: 10.7150/ijms.50167
关键词
hypertrophic cardiomyopathy; thromboembolism; stroke; anticoagulant therapy; atrial fibrillation
资金
- National Eighth Five-Year Research Plan, China [85-915-01-02]
- Mega-projects of Science Research for the 11th Five-Year Plan, China [2006BAI01A01]
- National Natural Science Foundation of China [81600299]
Hypertrophic cardiomyopathy (HCM) patients have various risk factors for predicting thromboembolic events, with traditional predictive models showing unsatisfactory results, prompting the need for modification or development of new models. Current guidelines recommend early identification of risk factors, accurate risk assessment, and aggressive management to prevent thromboembolic events in HCM patients.
Hypertrophic cardiomyopathy (HCM) is an inherited cardiac disease, which has a marked heterogeneity in clinical expression, natural history, and prognosis. HCM is associated with a high prevalence of thromboembolic events (stroke and systemic embolic events), even if taking no account of atrial fibrillation (AF), leading to unexpected disability and death in patients of all ages. Several risk factors of thromboembolism such as AF, greater age, left atrial diameter, heart failure and others have been confirmed in patients with HCM. Conventional thromboembolic predictive models were estimated by several trials in HCM population but it turned out to be unsatisfactory. Based on those previous explorations, researchers tried to modify or develop novel models suitable for HCM population in thromboembolism prediction. In consideration of catastrophic advent events of thromboembolism, current guidelines have recommended life-long anticoagulant therapy after a single short AF. Therefore, early identification of risk factors for thromboembolism, accurate risk stratification, timely preventive measures and aggressive management may help to avoid serious adverse thromboembolic events in HCM population.
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