期刊
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
卷 18, 期 4, 页码 964-974出版社
IVYSPRING INT PUBL
DOI: 10.7150/ijms.49460
关键词
STAT3; MicroRNA-15a; CX3CL1; Endothelial cells; Atherosclerosis
资金
- Natural Science Foundation of Hubei Province [2018CFB369]
- China Postdoctoral Science Foundation [2018M632927]
- Applied Basic Research Project of Wuhan City [2017060201010193]
- Hubei Provincial Plan of Natural Science Foundation of China [ZRMS2019000926]
- Hubei Province Technological Innovation Special Major Project [2019ACA168]
- General Project of Hubei Provincial Health Commission [WJ2019M255]
Endothelial cell proliferation disorder caused by vascular injury may be one of the causes of atherosclerosis, and miR-15a-5p could be a therapeutic target for coronary artery atherosclerosis.
Endothelial cell proliferation disorder caused by vascular injury seems to be one of the causes of atherosclerosis, which is the pathological basis of coronary heart disease. The role of STAT3 in the regulation of microRNAs and endothelial dysfunction in atherosclerosis is unclear. STAT3 can be activated by cytokine IL-6 and up regulate the expression of CX3CL1. In addition, microRNA-15a-5p (miR-15a-5p) inhibited the transcription of CX3CL1, the proliferation of vascular endothelial cells and the proliferation of STAT3 regulated vascular endothelial cells. STAT3 positively regulates the expression of CX3CL1, and then down-regulates the inhibition of CX3CL1 by over-expression of miR-15a-5p, thus forming an elimination feedback loop to control the proliferation of HUVECs and affect the progression of atherosclerosis. In conclusion, miR-15a-5p may be the therapeutic target of the pathological basis of coronary atherosclerosis.
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