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Baohong Zhang
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NATURE COMMUNICATIONS (2020)
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NATURE MEDICINE (2019)
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TRENDS IN BIOTECHNOLOGY (2019)
CRISPR-Cas for Fungal Genome Editing: A New Tool for the Management of Plant Diseases
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Editing the Sickle Cell Disease Mutation in Human Hematopoietic Stem Cells: Comparison of Endonucleases and Homologous Donor Templates
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Gene Therapy
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NEW ENGLAND JOURNAL OF MEDICINE (2019)
Highly efficient editing of the β-globin gene in patient-derived hematopoietic stem and progenitor cells to treat sickle cell disease
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NEW ENGLAND JOURNAL OF MEDICINE (2019)
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Extensive CRISPR RNA modification reveals chemical compatibility and structure-activity relationships for Cas9 biochemical activity
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APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2019)
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NUCLEIC ACIDS RESEARCH (2018)
Chimeric Guides Probe and Enhance Cas9 Biochemical Activity
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BIOCHEMISTRY (2018)
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CHEMICAL COMMUNICATIONS (2018)
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MOLECULAR THERAPY (2018)
Global Transcriptional Response to CRISPR/Cas9-AAV6-Based Genome Editing in CD34+ Hematopoietic Stem and Progenitor Cells
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MOLECULAR THERAPY (2018)
Partial DNA-guided Cas9 enables genome editing with reduced off-target activity
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NATURE CHEMICAL BIOLOGY (2018)
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NATURE COMMUNICATIONS (2018)
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NATURE COMMUNICATIONS (2018)
A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing
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CELL REPORTS (2018)
In vitro-transcribed guide RNAs trigger an innate immune response via the RIG-I pathway
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PLOS BIOLOGY (2018)
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Christopher A. Vakulskas et al.
NATURE MEDICINE (2018)
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Su Bin Moon et al.
NATURE COMMUNICATIONS (2018)
Extension of the crRNA enhances Cpf1 gene editing in vitro and in vivo
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NATURE COMMUNICATIONS (2018)
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Ting Xue et al.
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY (2018)
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CELL AND BIOSCIENCE (2018)
Applications of Gene Editing in Chickens: A New Era Is on the Horizon
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FRONTIERS IN GENETICS (2018)
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COMMUNICATIONS BIOLOGY (2018)
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SYNTHETIC AND SYSTEMS BIOTECHNOLOGY (2018)
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ACS CHEMICAL BIOLOGY (2018)
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NATURE (2017)
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Emily M. Harcourt et al.
NATURE (2017)
Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing
Hao Yin et al.
NATURE BIOTECHNOLOGY (2017)
CRISPR-Cas9-based photoactivatable transcription systems to induce neuronal differentiation
Yuta Nihongaki et al.
NATURE METHODS (2017)
Rapidly inducible Cas9 and DSB-ddPCR to probe editing kinetics
John C. Rose et al.
NATURE METHODS (2017)
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Sergey Shmakov et al.
NATURE REVIEWS MICROBIOLOGY (2017)
Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery
Thomas Gaj et al.
NUCLEIC ACIDS RESEARCH (2017)
CRISPR-Cas9 gene repair of hematopoietic stem cells from patients with X-linked chronic granulomatous disease
Suk See De Ravin et al.
SCIENCE TRANSLATIONAL MEDICINE (2017)
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Fernando Orden Rueda et al.
NATURE COMMUNICATIONS (2017)
Assembly of CRISPR ribonucleoproteins with biotinylated oligonucleotides via an RNA aptamer for precise gene editing
Jared Carlson-Stevermer et al.
NATURE COMMUNICATIONS (2017)
Advances in the delivery of RNA therapeutics: from concept to clinical reality
James C. Kaczmarek et al.
GENOME MEDICINE (2017)
Synthetically modified guide RNA and donor DNA are a versatile platform for CRISPR-Cas9 engineering
Kunwoo Lee et al.
ELIFE (2017)
RNA Interference-Induced Innate Immunity, Off-Target Effect, or Immune Adjuvant?
Zhongji Meng et al.
FRONTIERS IN IMMUNOLOGY (2017)
Engineering CRISPR-Cpf1 crRNAs and mRNAs to maximize genome editing efficiency
Bin Li et al.
NATURE BIOMEDICAL ENGINEERING (2017)
Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair
Kunwoo Lee et al.
NATURE BIOMEDICAL ENGINEERING (2017)
Minimal 2′-O-methyl phosphorothioate linkage modification pattern of synthetic guide RNAs for increased stability and efficient CRISPR-Cas9 gene editing avoiding cellular toxicity
Megan Basila et al.
PLOS ONE (2017)
Oncogenic Human Papillomavirus: Application of CRISPR/Cas9 Therapeutic Strategies for Cervical Cancer
Shuai Zhen et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2017)
BNANC Gapmers Revert Splicing and Reduce RNA Foci with Low Toxicity in Myotonic Dystrophy Cells
Kassie S. Manning et al.
ACS CHEMICAL BIOLOGY (2017)
Error-Prone Repair of DNA Double-Strand Breaks
Kasey Rodgers et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2016)
Rationally engineered Cas9 nucleases with improved specificity
Ian M. Slaymaker et al.
SCIENCE (2016)
Genome Editing: A New Approach to Human Therapeutics
Matthew Porteus
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 56 (2016)
Versatility of chemically synthesized guide RNAs for CRISPR-Cas9 genome editing
Melissa L. Kelley et al.
JOURNAL OF BIOTECHNOLOGY (2016)
CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells
Daniel P. Dever et al.
NATURE (2016)
High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects
Benjamin P. Kleinstiver et al.
NATURE (2016)
Multiplexed labeling of genomic loci with dCas9 and engineered sgRNAs using CRISPRainbow
Hanhui Ma et al.
NATURE BIOTECHNOLOGY (2016)
Genome-wide analysis reveals specificities of Cpf1 endonucleases in human cells
Daesik Kim et al.
NATURE BIOTECHNOLOGY (2016)
Defining and improving the genome-wide specificities of CRISPR-Cas9 nucleases
Shengdar Q. Tsai et al.
NATURE REVIEWS GENETICS (2016)
Engineering of temperature- and light-switchable Cas9 variants
Florian Richter et al.
NUCLEIC ACIDS RESEARCH (2016)
Long-term dual-color tracking of genomic loci by modified sgRNAs of the CRISPR/Cas9 system
Shipeng Shao et al.
NUCLEIC ACIDS RESEARCH (2016)
Selection-free genome editing of the sickle mutation in human adult hematopoietic stem/progenitor cells
Mark A. DeWitt et al.
SCIENCE TRANSLATIONAL MEDICINE (2016)
Structural roles of guide RNAs in the nuclease activity of Cas9 endonuclease
Youngbin Lim et al.
NATURE COMMUNICATIONS (2016)
Improved Genome Editing Efficiency and Flexibility Using Modified Oligonucleotides with TALEN and CRISPR-Cas9 Nucleases
Jean-Baptiste Renaud et al.
CELL REPORTS (2016)
DNA Damage Response and Immune Defense: Links and Mechanisms
Rania Nakad et al.
FRONTIERS IN GENETICS (2016)
An RNA-aptamer-based two-color CRISPR labeling system
Siyuan Wang et al.
SCIENTIFIC REPORTS (2016)
Targeted genome editing in primate embryos
Xiangyu Guo et al.
CELL RESEARCH (2015)
CRISPR-Cas9-based Photoactivatable Transcription System
Yuta Nihongaki et al.
CHEMISTRY & BIOLOGY (2015)
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Henriette O'Geen et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2015)
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Michel Morange
JOURNAL OF BIOSCIENCES (2015)
Systematic analysis of CRISPR-Cas9 mismatch tolerance reveals low levels of off-target activity
Emily M. Anderson et al.
JOURNAL OF BIOTECHNOLOGY (2015)
Rapid and highly efficient mammalian cell engineering via Cas9 protein transfection
Xiquan Liang et al.
JOURNAL OF BIOTECHNOLOGY (2015)
Optical Control of CRISPR/Cas9 Gene Editing
James Hemphill et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)
Conformational control of DNA target cleavage by CRISPR-Cas9
Samuel H. Sternberg et al.
NATURE (2015)
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
Silvana Konermann et al.
NATURE (2015)
Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells
Ayal Hendel et al.
NATURE BIOTECHNOLOGY (2015)
Inducible in vivo genome editing with CRISPR-Cas9
Lukas E. Dow et al.
NATURE BIOTECHNOLOGY (2015)
Photoactivatable CRISPR-Cas9 for optogenetic genome editing
Yuta Nihongaki et al.
NATURE BIOTECHNOLOGY (2015)
A light-inducible CRISPR-Cas9 system for control of endogenous gene activation
Lauren R. Polstein et al.
NATURE CHEMICAL BIOLOGY (2015)
Multiplexable, locus-specific targeting of long RNAs with CRISPR-Display
David M. Shechner et al.
NATURE METHODS (2015)
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Eric A. Josephs et al.
NUCLEIC ACIDS RESEARCH (2015)
A genome-wide analysis of Cas9 binding specificity using ChIP-seq and targeted sequence capture
Henriette O'Geen et al.
NUCLEIC ACIDS RESEARCH (2015)
Multicolor CRISPR labeling of chromosomal loci in human cells
Hanhui Ma et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Synthetic CRISPR RNA-Cas9-guided genome editing in human cells
Meghdad Rahdar et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
A Cas9-guide RNA complex preorganized for target DNA recognition
Fuguo Jiang et al.
SCIENCE (2015)
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Ayal Hendel et al.
TRENDS IN BIOTECHNOLOGY (2015)
Genome Engineering with Targetable Nucleases
Dana Carroll
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 83 (2014)
Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA
Hiroshi Nishimasu et al.
CELL (2014)
Development and Applications of CRISPR-Cas9 for Genome Engineering
Patrick D. Hsu et al.
CELL (2014)
Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases
Seung Woo Cho et al.
GENOME RESEARCH (2014)
Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
Yanfang Fu et al.
NATURE BIOTECHNOLOGY (2014)
Classification and evolution of type II CRISPR-Cas systems
Krzysztof Chylinski et al.
NUCLEIC ACIDS RESEARCH (2014)
Quantifying Genome-Editing Outcomes at Endogenous Loci with SMRT Sequencing
Ayal Hendel et al.
CELL REPORTS (2014)
One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering
Haoyi Wang et al.
CELL (2013)
Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System
Baohui Chen et al.
CELL (2013)
Genome engineering using the CRISPR-Cas9 system
F. Ann Ran et al.
NATURE PROTOCOLS (2013)
Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
Lijun Sun et al.
SCIENCE (2013)
RNA-Guided Human Genome Engineering via Cas9
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SCIENCE (2013)
Multiplex Genome Engineering Using CRISPR/Cas Systems
Le Cong et al.
SCIENCE (2013)
Designing Chemically Modified Oligonucleotides for Targeted Gene Silencing
Glen F. Deleavey et al.
CHEMISTRY & BIOLOGY (2012)
A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
Martin Jinek et al.
SCIENCE (2012)
Unique O-Methoxyethyl Ribose-DNA Chimeric Oligonucleotide Induces an Atypical Melanoma Differentiation-Associated Gene 5-Dependent Induction of Type I Interferon Response
Sebastien A. Burel et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2012)
CRISPR-based adaptive immune systems
Michael P. Terns et al.
CURRENT OPINION IN MICROBIOLOGY (2011)
Genome Engineering With Zinc-Finger Nucleases
Dana Carroll
GENETICS (2011)
RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform
C. Frank Bennett et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY (2010)
CRISPR/Cas, the Immune System of Bacteria and Archaea
Philippe Horvath et al.
SCIENCE (2010)
Molecular Mechanisms of Ultraviolet Radiation-Induced DNA Damage and Repair
Rajesh P. Rastogi et al.
JOURNAL OF NUCLEIC ACIDS (2010)
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OLIGONUCLEOTIDES (2009)
Chemical Modification of siRNAs for In Vivo Use
Mark A. Behlke
OLIGONUCLEOTIDES (2008)
Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo
AD Judge et al.
MOLECULAR THERAPY (2006)
Design of LNA probes that improve mismatch discrimination
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NUCLEIC ACIDS RESEARCH (2006)
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MH Porteus et al.
NATURE BIOTECHNOLOGY (2005)
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YL Chiu et al.
RNA (2003)
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BIOCHEMISTRY (2003)
DNA double-strand breaks trigger apoptosis in p53-deficient fibroblasts
J Lips et al.
CARCINOGENESIS (2001)