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Baohong Zhang
JOURNAL OF CELLULAR PHYSIOLOGY (2021)
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NATURE BIOTECHNOLOGY (2020)
Targeted gene correction of human hematopoietic stem cells for the treatment of Wiskott - Aldrich Syndrome
Rajeev Rai et al.
NATURE COMMUNICATIONS (2020)
Methods Favoring Homology-Directed Repair Choice in Response to CRISPR/Cas9 Induced-Double Strand Breaks
Han Yang et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
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Bo Hu et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)
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Sheetal Soni
CRISPR JOURNAL (2020)
Highly efficient therapeutic gene editing of human hematopoietic stem cells
Yuxuan Wu et al.
NATURE MEDICINE (2019)
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Su Bin Moon et al.
TRENDS IN BIOTECHNOLOGY (2019)
CRISPR-Cas for Fungal Genome Editing: A New Tool for the Management of Plant Diseases
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FRONTIERS IN PLANT SCIENCE (2019)
Editing the Sickle Cell Disease Mutation in Human Hematopoietic Stem Cells: Comparison of Endonucleases and Homologous Donor Templates
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MOLECULAR THERAPY (2019)
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NATURE BIOTECHNOLOGY (2019)
Engineered xCas9 and SpCas9-NG variants broaden PAM recognition sites to generate mutations in Arabidopsis plants
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Gene correction for SCID-X1 in long-term hematopoietic stem cells (vol 10, 1634, 2019)
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NATURE COMMUNICATIONS (2019)
CRISPR Cpf1 proteins: structure, function and implications for genome editing
Fatemeh Safari et al.
CELL AND BIOSCIENCE (2019)
Battling CRISPR-Cas9 off-target genome editing
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CELL BIOLOGY AND TOXICOLOGY (2019)
Gene Therapy
Katherine A. High et al.
NEW ENGLAND JOURNAL OF MEDICINE (2019)
Highly efficient editing of the β-globin gene in patient-derived hematopoietic stem and progenitor cells to treat sickle cell disease
So Hyun Park et al.
NUCLEIC ACIDS RESEARCH (2019)
An artificial triazole backbone linkage provides a split-and-click strategy to bioactive chemically modified CRISPR sgRNA
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Therapeutic potential of CRISPR/Cas9 gene editing in engineered T-cell therapy
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CANCER MEDICINE (2019)
CRISPR-Edited Stem Cells in a Patient with HIV and Acute Lymphocytic Leukemia
Lei Xu et al.
NEW ENGLAND JOURNAL OF MEDICINE (2019)
CRISPR-mediated live imaging of genome editing and transcription
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SCIENCE (2019)
Human genome-edited hematopoietic stem cells phenotypically correct Mucopolysaccharidosis type I
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NATURE COMMUNICATIONS (2019)
Development of a gene-editing approach to restore vision loss in Leber congenital amaurosis type 10
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NATURE MEDICINE (2019)
Treating Disease at the RNA Level with Oligonucleotides
Arthur A. Levin
NEW ENGLAND JOURNAL OF MEDICINE (2019)
Extensive CRISPR RNA modification reveals chemical compatibility and structure-activity relationships for Cas9 biochemical activity
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NUCLEIC ACIDS RESEARCH (2019)
CRISPR/Cas9 genome editing technology in filamentous fungi: progress and perspective
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APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2019)
At the intersection of DNA damage and immune responses
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NATURE REVIEWS IMMUNOLOGY (2019)
Improving CRISPR-Cas specificity with chemical modifications in single-guide RNAs
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NUCLEIC ACIDS RESEARCH (2018)
Chimeric Guides Probe and Enhance Cas9 Biochemical Activity
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BIOCHEMISTRY (2018)
Modifications and functional genomics of human transfer RNA
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CELL RESEARCH (2018)
A G-quadruplex motif at the 3 ' end of sgRNAs improves CRISPR-Cas9 based genome editing efficiency
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CHEMICAL COMMUNICATIONS (2018)
CRISPR RNAs trigger innate immune responses in human cells
Sojung Kim et al.
GENOME RESEARCH (2018)
Chemically Modified Cpf1-CRISPR RNAs Mediate Efficient Genome Editing in Mammalian Cells
Moira A. McMahon et al.
MOLECULAR THERAPY (2018)
Global Transcriptional Response to CRISPR/Cas9-AAV6-Based Genome Editing in CD34+ Hematopoietic Stem and Progenitor Cells
M. Kyle Cromer et al.
MOLECULAR THERAPY (2018)
Partial DNA-guided Cas9 enables genome editing with reduced off-target activity
Hao Yin et al.
NATURE CHEMICAL BIOLOGY (2018)
Incorporation of bridged nucleic acids into CRISPR RNAs improves Cas9 endonuclease specificity
Christopher R. Cromwell et al.
NATURE COMMUNICATIONS (2018)
Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing
Aamir Mir et al.
NATURE COMMUNICATIONS (2018)
A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing
Jonathan D. Finn et al.
CELL REPORTS (2018)
In vitro-transcribed guide RNAs trigger an innate immune response via the RIG-I pathway
Beeke Wienert et al.
PLOS BIOLOGY (2018)
A high-fidelity Cas9 mutant delivered as a ribonucleoprotein complex enables efficient gene editing in human hematopoietic stem and progenitor cells
Christopher A. Vakulskas et al.
NATURE MEDICINE (2018)
Highly efficient genome editing by CRISPR-Cpf1 using CRISPR RNA with a uridinylate-rich 3′-overhang
Su Bin Moon et al.
NATURE COMMUNICATIONS (2018)
Extension of the crRNA enhances Cpf1 gene editing in vitro and in vivo
Hyo Min Park et al.
NATURE COMMUNICATIONS (2018)
Improved bioethanol production using CRISPR/Cas9 to disrupt the ADH2 gene in Saccharomyces cerevisiae
Ting Xue et al.
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY (2018)
Class 2 CRISPR/Cas: an expanding biotechnology toolbox for and beyond genome editing
Yuyi Tang et al.
CELL AND BIOSCIENCE (2018)
Applications of Gene Editing in Chickens: A New Era Is on the Horizon
Hicham Sid et al.
FRONTIERS IN GENETICS (2018)
Increasing Cas9-mediated homology-directed repair efficiency through covalent tethering of DNA repair template
Eric J. Aird et al.
COMMUNICATIONS BIOLOGY (2018)
CRISPR-Cas9/Cas12a biotechnology and application in bacteria
Ruilian Yao et al.
SYNTHETIC AND SYSTEMS BIOTECHNOLOGY (2018)
A Single-Chain Photoswitchable CRISPR-Cas9 Architecture for Light-Inducible Gene Editing and Transcription
Xin X. Zhou et al.
ACS CHEMICAL BIOLOGY (2018)
Enhanced proofreading governs CRISPR-Cas9 targeting accuracy
Janice S. Chen et al.
NATURE (2017)
Chemical and structural effects of base modifications in messenger RNA
Emily M. Harcourt et al.
NATURE (2017)
Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing
Hao Yin et al.
NATURE BIOTECHNOLOGY (2017)
CRISPR-Cas9-based photoactivatable transcription systems to induce neuronal differentiation
Yuta Nihongaki et al.
NATURE METHODS (2017)
Rapidly inducible Cas9 and DSB-ddPCR to probe editing kinetics
John C. Rose et al.
NATURE METHODS (2017)
Diversity and evolution of class 2 CRISPR-Cas systems
Sergey Shmakov et al.
NATURE REVIEWS MICROBIOLOGY (2017)
Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery
Thomas Gaj et al.
NUCLEIC ACIDS RESEARCH (2017)
CRISPR-Cas9 gene repair of hematopoietic stem cells from patients with X-linked chronic granulomatous disease
Suk See De Ravin et al.
SCIENCE TRANSLATIONAL MEDICINE (2017)
Mapping the sugar dependency for rational generation of a DNA-RNA hybrid-guided Cas9 endonuclease
Fernando Orden Rueda et al.
NATURE COMMUNICATIONS (2017)
Assembly of CRISPR ribonucleoproteins with biotinylated oligonucleotides via an RNA aptamer for precise gene editing
Jared Carlson-Stevermer et al.
NATURE COMMUNICATIONS (2017)
Advances in the delivery of RNA therapeutics: from concept to clinical reality
James C. Kaczmarek et al.
GENOME MEDICINE (2017)
Synthetically modified guide RNA and donor DNA are a versatile platform for CRISPR-Cas9 engineering
Kunwoo Lee et al.
ELIFE (2017)
RNA Interference-Induced Innate Immunity, Off-Target Effect, or Immune Adjuvant?
Zhongji Meng et al.
FRONTIERS IN IMMUNOLOGY (2017)
Engineering CRISPR-Cpf1 crRNAs and mRNAs to maximize genome editing efficiency
Bin Li et al.
NATURE BIOMEDICAL ENGINEERING (2017)
Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair
Kunwoo Lee et al.
NATURE BIOMEDICAL ENGINEERING (2017)
Minimal 2′-O-methyl phosphorothioate linkage modification pattern of synthetic guide RNAs for increased stability and efficient CRISPR-Cas9 gene editing avoiding cellular toxicity
Megan Basila et al.
PLOS ONE (2017)
Oncogenic Human Papillomavirus: Application of CRISPR/Cas9 Therapeutic Strategies for Cervical Cancer
Shuai Zhen et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2017)
BNANC Gapmers Revert Splicing and Reduce RNA Foci with Low Toxicity in Myotonic Dystrophy Cells
Kassie S. Manning et al.
ACS CHEMICAL BIOLOGY (2017)
Error-Prone Repair of DNA Double-Strand Breaks
Kasey Rodgers et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2016)
Rationally engineered Cas9 nucleases with improved specificity
Ian M. Slaymaker et al.
SCIENCE (2016)
Genome Editing: A New Approach to Human Therapeutics
Matthew Porteus
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 56 (2016)
Versatility of chemically synthesized guide RNAs for CRISPR-Cas9 genome editing
Melissa L. Kelley et al.
JOURNAL OF BIOTECHNOLOGY (2016)
CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells
Daniel P. Dever et al.
NATURE (2016)
High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects
Benjamin P. Kleinstiver et al.
NATURE (2016)
Multiplexed labeling of genomic loci with dCas9 and engineered sgRNAs using CRISPRainbow
Hanhui Ma et al.
NATURE BIOTECHNOLOGY (2016)
Genome-wide analysis reveals specificities of Cpf1 endonucleases in human cells
Daesik Kim et al.
NATURE BIOTECHNOLOGY (2016)
Defining and improving the genome-wide specificities of CRISPR-Cas9 nucleases
Shengdar Q. Tsai et al.
NATURE REVIEWS GENETICS (2016)
Engineering of temperature- and light-switchable Cas9 variants
Florian Richter et al.
NUCLEIC ACIDS RESEARCH (2016)
Long-term dual-color tracking of genomic loci by modified sgRNAs of the CRISPR/Cas9 system
Shipeng Shao et al.
NUCLEIC ACIDS RESEARCH (2016)
Selection-free genome editing of the sickle mutation in human adult hematopoietic stem/progenitor cells
Mark A. DeWitt et al.
SCIENCE TRANSLATIONAL MEDICINE (2016)
Structural roles of guide RNAs in the nuclease activity of Cas9 endonuclease
Youngbin Lim et al.
NATURE COMMUNICATIONS (2016)
Improved Genome Editing Efficiency and Flexibility Using Modified Oligonucleotides with TALEN and CRISPR-Cas9 Nucleases
Jean-Baptiste Renaud et al.
CELL REPORTS (2016)
DNA Damage Response and Immune Defense: Links and Mechanisms
Rania Nakad et al.
FRONTIERS IN GENETICS (2016)
An RNA-aptamer-based two-color CRISPR labeling system
Siyuan Wang et al.
SCIENTIFIC REPORTS (2016)
Targeted genome editing in primate embryos
Xiangyu Guo et al.
CELL RESEARCH (2015)
CRISPR-Cas9-based Photoactivatable Transcription System
Yuta Nihongaki et al.
CHEMISTRY & BIOLOGY (2015)
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Henriette O'Geen et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2015)
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Michel Morange
JOURNAL OF BIOSCIENCES (2015)
Systematic analysis of CRISPR-Cas9 mismatch tolerance reveals low levels of off-target activity
Emily M. Anderson et al.
JOURNAL OF BIOTECHNOLOGY (2015)
Rapid and highly efficient mammalian cell engineering via Cas9 protein transfection
Xiquan Liang et al.
JOURNAL OF BIOTECHNOLOGY (2015)
Optical Control of CRISPR/Cas9 Gene Editing
James Hemphill et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)
Conformational control of DNA target cleavage by CRISPR-Cas9
Samuel H. Sternberg et al.
NATURE (2015)
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
Silvana Konermann et al.
NATURE (2015)
Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells
Ayal Hendel et al.
NATURE BIOTECHNOLOGY (2015)
Inducible in vivo genome editing with CRISPR-Cas9
Lukas E. Dow et al.
NATURE BIOTECHNOLOGY (2015)
Photoactivatable CRISPR-Cas9 for optogenetic genome editing
Yuta Nihongaki et al.
NATURE BIOTECHNOLOGY (2015)
A light-inducible CRISPR-Cas9 system for control of endogenous gene activation
Lauren R. Polstein et al.
NATURE CHEMICAL BIOLOGY (2015)
Multiplexable, locus-specific targeting of long RNAs with CRISPR-Display
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NATURE METHODS (2015)
Structure and specificity of the RNA-guided endonuclease Cas9 during DNA interrogation, target binding and cleavage
Eric A. Josephs et al.
NUCLEIC ACIDS RESEARCH (2015)
A genome-wide analysis of Cas9 binding specificity using ChIP-seq and targeted sequence capture
Henriette O'Geen et al.
NUCLEIC ACIDS RESEARCH (2015)
Multicolor CRISPR labeling of chromosomal loci in human cells
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Synthetic CRISPR RNA-Cas9-guided genome editing in human cells
Meghdad Rahdar et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
A Cas9-guide RNA complex preorganized for target DNA recognition
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SCIENCE (2015)
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TRENDS IN BIOTECHNOLOGY (2015)
Genome Engineering with Targetable Nucleases
Dana Carroll
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 83 (2014)
Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA
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CELL (2014)
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CELL (2014)
Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases
Seung Woo Cho et al.
GENOME RESEARCH (2014)
Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
Yanfang Fu et al.
NATURE BIOTECHNOLOGY (2014)
Classification and evolution of type II CRISPR-Cas systems
Krzysztof Chylinski et al.
NUCLEIC ACIDS RESEARCH (2014)
Quantifying Genome-Editing Outcomes at Endogenous Loci with SMRT Sequencing
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CELL REPORTS (2014)
One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering
Haoyi Wang et al.
CELL (2013)
Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System
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CELL (2013)
Genome engineering using the CRISPR-Cas9 system
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NATURE PROTOCOLS (2013)
Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
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SCIENCE (2013)
RNA-Guided Human Genome Engineering via Cas9
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SCIENCE (2013)
Multiplex Genome Engineering Using CRISPR/Cas Systems
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SCIENCE (2013)
Designing Chemically Modified Oligonucleotides for Targeted Gene Silencing
Glen F. Deleavey et al.
CHEMISTRY & BIOLOGY (2012)
A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
Martin Jinek et al.
SCIENCE (2012)
Unique O-Methoxyethyl Ribose-DNA Chimeric Oligonucleotide Induces an Atypical Melanoma Differentiation-Associated Gene 5-Dependent Induction of Type I Interferon Response
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JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2012)
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Michael P. Terns et al.
CURRENT OPINION IN MICROBIOLOGY (2011)
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Dana Carroll
GENETICS (2011)
RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform
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ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY (2010)
CRISPR/Cas, the Immune System of Bacteria and Archaea
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SCIENCE (2010)
Molecular Mechanisms of Ultraviolet Radiation-Induced DNA Damage and Repair
Rajesh P. Rastogi et al.
JOURNAL OF NUCLEIC ACIDS (2010)
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OLIGONUCLEOTIDES (2009)
Chemical Modification of siRNAs for In Vivo Use
Mark A. Behlke
OLIGONUCLEOTIDES (2008)
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AD Judge et al.
MOLECULAR THERAPY (2006)
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NUCLEIC ACIDS RESEARCH (2006)
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NATURE BIOTECHNOLOGY (2005)
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RNA (2003)
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BIOCHEMISTRY (2003)
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