期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 19, 期 1, 页码 82-100出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ob02079f
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资金
- Institute of Cancer Therapeutics (University of Bradford) Doctoral Training Centre
Glycosyl disulfides, rare in nature, have gained significant attention as glycomimetics with wide applications in biology and therapeutics. Researchers are continuously developing new methods for synthesizing glycosyl disulfides to further explore their potential in studying carbohydrate structures and metabolic pathways.
The disulfide bond plays an important role in the formation and stabilisation of higher order structures of peptides and proteins, while in recent years interest in this functional group has been extended to carbohydrate chemistry. Rarely found in nature, glycosyl disulfides have attracted significant attention as glycomimetics, with wide biological applications including lectin binding, as key components of dynamic libraries to study carbohydrate structures, the study of metabolic and enzymatic studies, and even as potential drug molecules. This interest has been accompanied and fuelled by the continuous development of new methods to construct the disulfide bond at the anomeric centre. Glycosyl disulfides have also been exploited as versatile intermediates in carbohydrate synthesis, particularly as glycosyl donors. This review focuses on the importance of the disulfide bond in glycobiology and in chemistry, evaluating the different methods available to synthesise glycosyl disulfides. Furthermore, we review the role of glycosyl disulfides as intermediates and/or glycosyl donors for the synthesis of neoglycoproteins and oligosaccharides, before finally considering examples of how this important class of carbohydrates have made an impact in biological and therapeutic contexts.
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