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Reframing primary alkyl amines as aliphatic building blocks

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ORGANIC & BIOMOLECULAR CHEMISTRY
卷 19, 期 1, 页码 11-36

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ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ob01807d

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  1. University of Chicago

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While traditionally considered inert to substitution chemistry, primary aliphatic amines have been shown to be valuable C(sp(3)) synthons in recent advances in aliphatic deamination chemistry. Cross-coupling and photocatalyzed transformations using polar and radical mechanisms are compared with oxidative deamination and other transition metal catalyzed reactions.
While primary aliphatic amines are ubiquitous in natural products, they are traditionally considered inert to substitution chemistry. This review highlights historical and recent advances in the field of aliphatic deamination chemistry which demonstrate these moieties can be harnessed as valuable C(sp(3)) synthons. Cross-coupling and photocatalyzed transformations proceeding through polar and radical mechanisms are compared with oxidative deamination and other transition metal catalyzed reactions.

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