期刊
JOURNAL OF NEUROSCIENCE
卷 41, 期 1, 页码 61-72出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0236-20.2020
关键词
avoidance; central amygdala; HCN channels; lateral hypothalamus; stress
资金
- National Institutes of Health [AA023305, AA026531, AA026022, AA027145, AA007577]
- United States Department of Veterans Affairs, Biomedical Laboratory Research and Development Service [I01 BX003451]
The study demonstrates the crucial role of CeA projections to the lateral hypothalamus in avoidance behavior of male rats exposed to stress-related stimuli, suggesting potential implications for substance abuse and traumatic stress disorders. Moreover, the avoidance behavior is found to be associated with intrinsic properties of LH-projecting CeA cells.
Persistent avoidance of stress-related stimuli following acute stress exposure predicts negative outcomes such as substance abuse and traumatic stress disorders. Previous work using a rat model showed that the central amygdala (CeA) plays an important role in avoidance of a predator odor stress-paired context. Here, we show that CeA projections to the lateral hypothalamus (LH) are preferentially activated in male rats that show avoidance of a predator odor-paired context (termed Avoider rats), that chemogenetic inhibition of CeA-LH projections attenuates avoidance in male Avoider rats, that chemogenetic stimulation of the CeA-LH circuit produces conditioned place avoidance (CPA) in otherwise naive male rats, and that avoidance behavior is associated with intrinsic properties of LH-projecting CeA cells. Collectively, these data show that CeALH projections are important for persistent avoidance of stress-related stimuli following acute stress exposure.
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