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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
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Fangnian Wang et al.
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Suppression of inflammation by a synthetic histone mimic
Edwige Nicodeme et al.
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The role of innate immune pathways in type 1 diabetes pathogenesis
Steven C. Pino et al.
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY (2010)
Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses
Trine H. Mogensen
CLINICAL MICROBIOLOGY REVIEWS (2009)
Double Bromodomain-Containing Gene Brd2 Is Essential for Embryonic Development in Mouse
Enyuan Shang et al.
DEVELOPMENTAL DYNAMICS (2009)
Brd4 Coactivates Transcriptional Activation of NF-κB via Specific Binding to Acetylated RelA
Bo Huang et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Cooperative binding of two acetylation marks on a histone tail by a single bromodomain
Jeanne Moriniere et al.
NATURE (2009)
The Nuclear Factor NF-κB Pathway in Inflammation
Toby Lawrence
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2009)
Epigenetic control of T-helper-cell differentiation
Christopher B. Wilson et al.
NATURE REVIEWS IMMUNOLOGY (2009)
The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulation
Shwu-Yuan Wu et al.
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Crystal structure of the human BRD2 bromodomain - Insights into dimerization and recognition of acetylated histone H4
Yoshihiro Nakamura et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Immunopathogenesis: Role of innate and adaptive immune responses
K Visvanathan et al.
SEMINARS IN LIVER DISEASE (2006)
Histone structure and nucleosome stability
Leonardo Marino-Ramirez et al.
EXPERT REVIEW OF PROTEOMICS (2005)
Differentially expressed genes in endothelial differentiation
H Ishii et al.
DNA AND CELL BIOLOGY (2005)
The E2F transcriptional network: old acquaintances with new faces
DK Dimova et al.
ONCOGENE (2005)
Involvement of the toll-like receptor 9 signaling pathway in the induction of innate immunity by baculovirus
T Abe et al.
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STAT proteins:: From normal control of cellular events to tumorigenesis
V Calò et al.
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NALPs: A novel protein family involved in inflammation
J Tschopp et al.
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Cutting edge: Role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins
O Takeuchi et al.
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RNA polymerase II carboxy-terminal domain kinases: Emerging clues to their function
G Prelich
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Histone acetylation: a switch between repressive and permissive chromatin - Second in review series on chromatin dynamics
A Eberharter et al.
EMBO REPORTS (2002)
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
L Alexopoulou et al.
NATURE (2001)
Duration of nuclear NF-κB action regulated by reversible acetylation
LF Chen et al.
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Host responses to Plasmodium yoelii hepatic stages:: A paradigm in host-parasite interaction
AOT Lau et al.
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Advances in immunology: Innate immunity.
R Medzhitov et al.
NEW ENGLAND JOURNAL OF MEDICINE (2000)
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