期刊
RSC ADVANCES
卷 11, 期 3, 页码 1271-1281出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ra09562a
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资金
- CSIR, New Delhi
The green and widespread β-cyclodextrin serves as an efficient promoter in metal-free one-pot multi-component synthesis of highly functionalized bioactive heterocyclic moieties. The organic supramolecule plays a crucial role in these reactions by being able to synthesize such moieties from easily available precursor aldehydes.
beta-Cyclodextrin, a green and widespread supramolecular catalyst, has been explored as a highly proficient promoter for the metal-free one-pot multi-component synthesis of a vast range of highly functionalized bioactive heterocyclic moiety, 2-amino-4,6-diphenylnicotinonitriles and 2,3-dihydroquinazolin-4(1H)-one, from easily available precursor aldehydes. The main endeavor of these protocols is to explore this organic supramolecule in one-pot multi-component synthesis. Absence of metal catalyst or toxic acid and harsh reaction conditions, excellent functional group tolerance, inexpensive, greener and environmentally safe protocol are the key advantages of this work.
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