Transition-metal-free synthesis of 5-amino-1,2,3-triazoles via nucleophilic addition/cyclization of carbodiimides with diazo compounds

A simple and transition-metal-free strategy to construct 5-amino-1,2,3-triazoles using carbodiimides and diazo compounds has been developed. This protocol involves a cascade nucleophilic addition/cyclization process and is accomplished under mild conditions. Further functionalization enriched the molecular diversity of triazoles. Control experiments and DFT calculations clarify the reaction mechanism and rationalize the kinetic and thermodynamic selectivity observed in the transformation. The late-stage derivatization and gram-scale synthesis reveal the promising utility of this methodology.

Automated summary

A simple and transition-metal-free strategy has been developed for constructing 5-amino-1,2,3-triazoles, enriching their molecular diversity through further functionalization. Control experiments and DFT calculations clarify the reaction mechanism, while late-stage derivatization and gram-scale synthesis demonstrate the promising utility of this methodology.