相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Impaired Clearance From the Brain Increases the Brain Exposure to Metoclopramide in Elderly Subjects
Martin Bauer et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2021)
Impact of P-Glycoprotein Function on the Brain Kinetics of the Weak Substrate 11C-Metoclopramide Assessed with PET Imaging in Humans
Nicolas Tournier et al.
JOURNAL OF NUCLEAR MEDICINE (2019)
Positron Emission Tomography Imaging Reveals an Importance of Saturable Liver Uptake Transport for the Pharmacokinetics of Metoclopramide
Fabien Caille et al.
CONTRAST MEDIA & MOLECULAR IMAGING (2018)
P-Glycoprotein (ABCB1) Inhibits the Influx and Increases the Efflux of C-11-Metoclopramide Across the Blood-Brain Barrier: A PET Study on Nonhuman Primates
Sylvain Auvity et al.
JOURNAL OF NUCLEAR MEDICINE (2018)
Imaging techniques to study drug transporter function in vivo
Nicolas Tournier et al.
PHARMACOLOGY & THERAPEUTICS (2018)
Possible Role of Organic Cation Transporters in the Distribution of [11C]Sulpiride, a Dopamine D2 Receptor Antagonist
Harumasa Takano et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2017)
Imaging the Impact of the P-Glycoprotein (ABCB1) Function on the Brain Kinetics of Metoclopramide
Geraldine Pottier et al.
JOURNAL OF NUCLEAR MEDICINE (2016)
[11C]-Labeled Metformin Distribution in the Liver and Small Intestine Using Dynamic Positron Emission Tomography in Mice Demonstrates Tissue-Specific Transporter Dependency
Jonas B. Jensen et al.
DIABETES (2016)
Utility of Cerebrospinal Fluid Drug Concentration as a Surrogate for Unbound Brain Concentration in Nonhuman Primates
Yoko Nagaya et al.
DRUG METABOLISM AND PHARMACOKINETICS (2014)
Metoclopramide is metabolized by CYP2D6 and is a reversible inhibitor, but not inactivator, of CYP2D6
Mara R. Livezey et al.
XENOBIOTICA (2014)
Organic Cation Transporter OCTs (SLC22) and MATEs (SLC47) in the Human Kidney
Hideyuki Motohashi et al.
AAPS JOURNAL (2013)
Identification of Novel Substrates and Structure-Activity Relationship of Cellular Uptake Mediated by Human Organic Cation Transporters 1 and 2
Ramon Hendrickx et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Clinical Response and Side Effects of Metoclopramide Associations With Clinical, Demographic, and Pharmacogenetic Parameters
Henry P. Parkman et al.
JOURNAL OF CLINICAL GASTROENTEROLOGY (2012)
Ablation of Both Organic Cation Transporter (Oct)1 and Oct2 Alters Metformin Pharmacokinetics but Has No Effect on Tissue Drug Exposure and Pharmacodynamics
J. William Higgins et al.
DRUG METABOLISM AND DISPOSITION (2012)
Competitive Inhibition of the Luminal Efflux by Multidrug and Toxin Extrusions, but Not Basolateral Uptake by Organic Cation Transporter 2, Is the Likely Mechanism Underlying the Pharmacokinetic Drug-Drug Interactions Caused by Cimetidine in the Kidney
Sumito Ito et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2012)
Quantitative Prediction of Cytochrome P450 (CYP) 2D6-Mediated Drug Interactions
Michel Tod et al.
CLINICAL PHARMACOKINETICS (2011)
Membrane transporters in drug development
Kathleen M. Giacomini et al.
NATURE REVIEWS DRUG DISCOVERY (2010)
Identification of Novel Metoclopramide Metabolites in Humans: In Vitro and In Vivo Studies
Upendra A. Argikar et al.
DRUG METABOLISM AND DISPOSITION (2010)
Biowaiver monographs for immediate release solid oral dosage forms: Metoclopramide hydrochloride
A. G. Stosik et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2008)
The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations
Hiroshi Omote et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2006)
The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: Evaluation using the MDR1A/1B knockout mouse model
A Doran et al.
DRUG METABOLISM AND DISPOSITION (2005)
Deficiency in the organic cation transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in mice abolishes renal secretion of organic cations
JW Jonker et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
The gastroprokinetic and antiemetic drug metoclopramide is a substrate and inhibitor of cytochrome P450 2D6
Z Desta et al.
DRUG METABOLISM AND DISPOSITION (2002)
Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (Oct1 [Slc22a1]) gene
JW Jonker et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
分享论文
