期刊
CHEMICAL COMMUNICATIONS
卷 57, 期 2, 页码 251-254出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc06357f
关键词
-
资金
- DST-SERB [CRG/2020/003424]
- BITS Pilani
- DST-FIST [SR/FST/CSI-270/2015]
The study developed a simple multicomponent method for synthesizing beta-substituted pyrroles, using aqueous succinaldehyde, primary amines, and isatins. The research delved into the direct synthesis of beta-substituted free NH-pyrrole, and DFT calculations and preliminary mechanism investigation supported a possible reaction pathway.
The synthesis of beta-(C3)-functionalized pyrroles is a challenging task and requires a multistep protocol. An operationally simple direct catalytic synthesis of beta-substituted pyrroles has been developed. This one-pot multicomponent method combined aqueous succinaldehyde as 1,4-dicarbonyl, primary amines, and isatins to access hydroxyl-oxindole beta-tethered pyrroles. Direct synthesis of the beta-substituted free NH-pyrrole is the central intensity of this work. DFT-calculations and preliminary mechanism investigation support the possible reaction pathway.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据