期刊
JGH OPEN
卷 5, 期 2, 页码 307-311出版社
WILEY
DOI: 10.1002/jgh3.12492
关键词
Helicobacter pylori; hypersensitivity; metronidazole; sitafloxacin; vonoprazan
资金
- Yokohama City University
The study demonstrates that the 7-day VPZ-MNZ-STFX rescue therapy has a high eradication rate of H. pylori in patients with penicillin allergy, with good tolerability, particularly in terms of completing the medication course.
Background and Aim To assess the efficacy and safety of 7-day Helicobacter pylori rescue treatment consisting of a vonoprazan (VPZ), metronidazole (MNZ), and sitafloxacin (STFX) regimen (VPZ-MNZ-STFX therapy) in patients with penicillin allergy. Methods This was a registered prospective intervention study. Patients with penicillin allergy who were diagnosed with H. pylori infection and had a history of H. pylori eradication were eligible for inclusion. Seventeen patients were prospectively treated with VPZ 20 mg bid, MNZ 250 mg bid, and STFX 100 mg bid for 7 days. Safety was evaluated using a questionnaire on adverse effects. Results The eradication rate of 7-day VPZ-MNZ-SFTX therapy was 88.2% (95% confidence interval: 63.6-98.5%; n = 17) in both intention-to-treat and per-protocol analyses. On the questionnaire, 25% of patients reported experiencing diarrhea, with a score of 2 or 3. All patients undergoing VPZ-MNZ-STFX therapy completed 100% of their medication course. Conclusion Rescue H. pylori eradication with VPZ-MNZ-STFX therapy is effective and well tolerated in patients with penicillin allergy (UMIN000016335, jRCTs031180133).
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