4.7 Article

Real-time imaging of alkaline phosphatase activity of diabetes in mice via a near-infrared fluorescent probe

期刊

CHEMICAL COMMUNICATIONS
卷 57, 期 4, 页码 480-483

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc07292c

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资金

  1. National Natural Science Foundation of China [21775133]
  2. Hunan Provincial Natural Science Foundation [2018JJ2385]
  3. Scientific Research Fund of Hunan Provincial Education Department [19A479]
  4. Degree & Postgraduate Education Reform Project of Hunan Province [CX20190483, XDCX2020B115]

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A novel water-soluble near-infrared fluorescent probe QX-P with simple synthesis has been developed, showing high sensitivity and selectivity to ALP. The probe is able to visualize ALP activity in four cell lines and real-time image ALP activity during the diagnosis and treatment of diabetes in mice.
A novel water-soluble near-infrared fluorescent probe named QX-P with simple synthesis is developed. QX-P has high sensitivity and selectivity to ALP. Moreover, the probe can not only visualize ALP activity in four cell lines, but also real-time image ALP activity during the diagnosis and treatment of diabetes in mice.

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