期刊
NEW JOURNAL OF CHEMISTRY
卷 45, 期 2, 页码 1020-1028出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0nj05069e
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资金
- College for Advanced Performance Studies, Babe-Bolyai University
- Babe-Bolyai University
The study aims to evaluate the antiproliferative activity of various organotin(iv) compounds to better understand the structure-activity relationship. The novel organotin(iv) species synthesized show potential for pharmacological applications.
In recent decades, organotin(iv) chemistry has seen a rapid growth owing to the biological, pharmaceutical and medicinal applications found for different compounds. The aim of this study was the evaluation of the antiproliferative activity of several organotin(iv) compounds for a better understanding of the structure-activity relationship (SAR). The synthesis and structural features of the new organotin(iv) species are also presented. Thus, the treatment of [2-{(CH2O)(2)CH}C6H4]Me2SnCl (1) and [2-(O = CH)C6H4]Me2SnCl (2) with potassium salts of isonicotinic and nicotinic acids resulted in the isolation of [2-{(CH2O)(2)CH}C6H4]Me2Sn[O(O)CC5H4N-4] (3), [2-{(CH2O)(2)CH}C6H4]Me2Sn[O(O)CC5H4N-3] (4), [2-(O = CH)C6H4]Me2Sn[O(O)CC5H4N-4] (5) and [2-(O = CH)C6H4]Me2Sn[O(O)CC5H4N-3] (6), respectively, in high yields. The one pot reaction between compound 2, isonicotinic acid and sodium hydroxide allows the formation of [2-(EtOOC)C6H4]Me2Sn[O(O)(CC5H4N-4)] (7) in a moderate yield. The novel compounds were characterized by multinuclear NMR spectroscopy, mass spectrometry and IR spectroscopy. The molecular structures of compounds 3-5 and 7 were established via single crystal X-ray diffraction; in all cases a distorted trigonal bipyramidal coordination geometry was found around the metal center, as a result of the strong intramolecular O -> Sn coordination. Compounds 1-6 were investigated for their in vitro antiproliferative activity towards the mouse colon carcinoma C26 cell line with the preliminary results showing a better activity than that of 5-fluorouracil.
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