期刊
CHEMICAL COMMUNICATIONS
卷 57, 期 4, 页码 540-543出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc07400d
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资金
- THE ISRAEL SCIENCE FOUNDATION [476/17]
- David R. Bloom Center for Pharmacy
- Alex Grass Center for Drug Design and Synthesis of Novel Therapeutics
The cpFIT-PNA probes are highly emissive RNA sensors with improved mismatch discrimination compared to FIT-PNAs.
Cyclopentane modified FIT-PNA (cpFIT-PNA) probes are reported as highly emissive RNA sensors with the highest reported brightness for FIT-PNAs. Compared to FIT-PNAs, cpFIT-PNAs have improved mismatch discrimination for several pyrimidine-pyrimidine single nucleotide variants (SNVs).
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