Transition metal catalyzed asymmetric multicomponent reactions of unsaturated compounds using organoboron reagents

Asymmetric multicomponent reactions allow stitching several functional groups in an enantioselective and atom economical manner. The introduction of boron-based reagents as a multicomponent coupling partner has its own merits. In addition to being non-toxic and highly stable, organoboron compounds can be easily converted to other functional groups in a stereoselective manner. In the last decade several transition metal catalyzed asymmetric multicomponent strategies have been evolved using boron based reagents. This review will discuss the merits and scope of multicomponent strategies based on their difference in the reaction mechanism and transition metals involved.

Automated summary

Asymmetric multicomponent reactions allow the stitching of multiple functional groups in an enantioselective and atom economical manner. The use of boron-based reagents in such reactions offers advantages such as non-toxicity, high stability, and easy conversion to other functional groups in a stereoselective manner. In the past decade, several transition metal catalyzed asymmetric multicomponent strategies using boron-based reagents have been developed.