C(sp2)-H functionalization in non-aromatic azomethine-based heterocycles

Direct C(sp(2))-H functionalization of the endocyclic azomethine and aldonitrone moieties in non-aromatic azaheterocycles has established itself as a promising methodology over the last decade. Transition metal-catalyzed cross-coupling reactions, alpha-metalation-electrophile quenching protocols, and (metal-free) nucleophilic substitution of hydrogen reactions (S-N(H)) are the major routes applied on cyclic imines and their derivatives. In this overview, we show the tangible progress made in this area during the period from 2008 to 2020.

Automated summary

In the past decade, direct C(sp(2))-H functionalization of the endocyclic azomethine and aldonitrone moieties in non-aromatic azaheterocycles has emerged as a promising methodology, with major routes being transition metal-catalyzed cross-coupling reactions, alpha-metalation-electrophile quenching protocols, and (metal-free) nucleophilic substitution of hydrogen reactions (S-N(H)) applied on cyclic imines and their derivatives. Significant progress has been made in this area between 2008 and 2020.