Dysfunction of natural killer cells in end-stage kidney disease on hemodialysis

Natural killer (NK) cells are known to play an important role in defense against infection and tumors. Although there is no clear consensus, most studies have shown that the number and cytotoxicity of NK cells decreases in end-stage kidney disease (ESKD) patients undergoing hemodialysis. Uremic patients chronically suffer from oxidative stress, which could be responsible for downregulation of the activating receptors on NK cells and modulation of ligand expression for activating receptors. Theoretically, the reduced number of NK cells and decreased function might increase susceptibility to viral infections and cancer development in patients with ESKD. There is emerging evidence that NK cell numbers may be an outcome predictor in renal transplantation; however, the clinical significance of NK cell dysfunction in dialysis patients requires clarification. In this review, I describe NK cell number, cytotoxic activity, and activating mechanisms in the context of uremia and oxidative stress, which is anticipated to assist in elucidating the mechanisms underlying immunodeficiency in dialysis patients.

Automated summary

NK cells, which are essential in defense against infections and tumors, decrease in both number and cytotoxicity in patients with ESKD undergoing hemodialysis. This decrease might increase susceptibility to viral infections and cancer development. While NK cell numbers may predict outcomes in renal transplantation, further research is needed to clarify the clinical significance of NK cell dysfunction in dialysis patients.