期刊
RSC ADVANCES
卷 11, 期 6, 页码 3429-3438出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ra08900a
关键词
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资金
- Russian Science Foundation (RSF) [17-73-20260]
- Wellcome Trust (UK)
- University of Queensland (Australia)
- Russian Science Foundation [20-73-20023] Funding Source: Russian Science Foundation
The synthesized novel gemini quaternary ammonium compounds showed strong bacteriostatic activity against a wide range of bacteria and fungi. Some of these compounds exhibited a wider and more potent antimicrobial spectrum than commonly-used antiseptics.
Eighteen novel gemini quaternary ammonium compounds were synthesized to examine the effect of linker nature, aliphatic chain length and their relative position on antibacterial and antifungal activity. The synthesized compounds showed strong bacteriostatic activity against a panel of both Gram-positive and Gram-negative bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and two fungi. Some of these compounds exhibited a wider and more potent antimicrobial spectrum than commonly-used antiseptics, such as benzalkonium chloride (BAC), cetylpyridinium chloride (CPC), chlorhexidine digluconate (CHG) and octenidine dihydrochloride (OCT).
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