期刊
JOURNAL OF ADVANCED PHARMACEUTICAL TECHNOLOGY & RESEARCH
卷 12, 期 1, 页码 89-93出版社
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/japtr.JAPTR_105_20
关键词
Actinomyces viscosus; C10 Massoia lactone; Lactobacillus acidophilus; polymicrobial biofilms; scanning electron microscope; Streptococcus spp
资金
- Ministry of Research and Technology/National Agency for Research and Innovation (Indonesia) [3166/UN1.DITLIT/DIT-LIT/PT/2020]
- Enhancing International Publication Program 2020 in Leiden University
This study investigated the efficacy of C-10 Massoia lactone in oral polymicrobial degradation, demonstrating its ability to degrade biofilms and destroy extracellular polymeric substances. Further research is needed to confirm these findings.
This study is aimed to test the efficacy of C-10 Massoia lactone in oral polymicrobial degradation. Polymicrobial of Streptococcus sanguinis, Streptococcus mutans, Lactobacillus acidophilus, and Actinomyces viscosus were studied. C-10 Massoia lactone against biofilm degradation was investigated using modified crystal violet for biofilm staining. The effectiveness of C-10 Massoia lactone against biofilms was calculated by the minimum biofilm inhibitory concentration (MBIC50) and the minimum value of biofilm eradication concentration (MBEC50). Scanning electron microscope was used to study biofilm cell viability and morphological changes. The results showed a degradation effect of C-10 Massoia lactone against mature oral polymicrobial at 0.25% v/v. C-10 Massoia lactone can degrade polymicrobial biofilms of S. mutans, S. sanguinis, L. acidophilus and A. viscosus. This compound can destroy the extracellular polymeric substances (EPS) of polymicrobial biofilms. The potential application of C-10 Massoia lactone for anti-polymicrobial medication should be applied in such a way that any negative effects are minimized. Further research is needed to confirm the findings of this study.
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