Metal-free syntheses of N-functionalized and NH-1,2,3-triazoles: an update on recent developments

An overview of the latest developments in the metal-free synthesis of non-benzo-fused N-functionalized and NH-1,2,3-triazoles is provided in this feature article. Synthetic studies that appeared from 2016 until August 2020 are organized according to a wide-ranging classification, comprising oxidative and eliminative azide-dipolarophile cycloadditions, diazo transfer reactions and N-tosylhydrazone-mediated syntheses. The newly developed methods constitute a significant contribution to the field of 1,2,3-triazole synthesis in terms of structural variation via either the exploration of novel reactions, or the exploitation of existing methodologies.

Automated summary

This article provides an overview of the latest developments in metal-free synthesis of non-benzo-fused N-functionalized and NH-1,2,3-triazoles, including oxidative and eliminative azide-dipolarophile cycloadditions, diazo transfer reactions, and N-tosylhydrazone-mediated syntheses. These newly developed methods have significantly contributed to the field of 1,2,3-triazole synthesis by exploring novel reactions and utilizing existing methodologies for structural variation.