期刊
ORGANIC CHEMISTRY FRONTIERS
卷 8, 期 2, 页码 -出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0qo00699h
关键词
-
资金
- National Natural Science Foundation of China [21772069, 21831007]
- Six Kinds of Talents Project of Jiangsu Province [SWYY-025]
- Undergraduate Students Project of Jiangsu Province
- Natural Science Research Project of Jiangsu Higher Education Institutions of China [18KJB150031]
- TAPP
The study established a reaction under the cooperative bimetallic catalysis of iridium and copper catalysts, which yielded indole C3-allylation products with moderate yields (up to 78%) and good enantioselectivities (up to 97:3 er). This reaction not only represents the first catalytic asymmetric ring-opening reaction of vinylcyclopropanes with C3-unsubstituted indoles, but also provides an atom-economic and straightforward method for the synthesis of C3-allylic indoles with high regio- and enantioselectivity.
The title reaction has been established under the cooperative bimetallic catalysis of iridium and copper catalysts, which afforded indole C3-allylation products with branched selectivity in moderate yields (up to 78%) and good enantioselectivities (up to 97 : 3 er). This reaction not only represents the first catalytic asymmetric ring-opening reaction of vinylcyclopropanes with C3-unsubstituted indoles, but also has provided an atom-economic and straightforward method for the synthesis of C3-allylic indoles with high regio- and enantioselectivity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据