4.7 Article

Wash-free 3D imaging and detection of glioma with a novel neuropotential targeted AIE probe

期刊

CHEMICAL COMMUNICATIONS
卷 57, 期 6, 页码 801-804

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc07289c

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资金

  1. National Natural Science Foundation of China [81971678, 81671756]
  2. Hunan Provincial Science and Technology Plan [2016TP2002]
  3. Science and Technology Foundation of Hunan Province [2020SK3019, 2019SK2211, 2019GK5012]
  4. Fundamental Research Funds for the Central Universities of Central South University [2018zzts041, 2018dcyj067]

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The novel tetraarylimidazole-based AIE probe TPIG-NP allows selective imaging and quantitative detection of glioma, utilizing the distinct negatively charged glioma cells for wash-free imaging.
We herein developed a novel tetraarylimidazole-based AIE probe TPIG-NP to selectively image and quantitatively detect glioma. Due to the distinct negatively charged glioma cells, TPIG-NP with an opposite charge could achieve wash-free imaging of glioma cells and 3D multicellular spheroids.

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