期刊
CHINESE MEDICAL JOURNAL
卷 134, 期 4, 页码 379-389出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/CM9.0000000000001243
关键词
Long non-coding RNAs (LncRNA); Psoriasis; Keratinocytes; T cells; Dendritic cells
资金
- National Key Research and Development Program of China [2018YFC1705305]
- National Natural Science Foundation of China [81973860, 81904214, 81671959, U1704171, 82004235]
- Shanghai Development Office of Traditional Chinese Medicine [(2018-2020)FWTX-1008, (2018-2020)-CCCX-2004-08, (2018-2020)-FWTX-4010]
- Hundred Talents Program of Shaanxi [SXBR9053]
- Science and Technology Commission of Shanghai Municipality [18401933500]
- Shanghai Key Clinical Specialties Construction Project of Dermatology of Traditional Chinese Medicine [shslczdzk05001]
This review provides an overview of recent studies investigating mechanisms and functions of lncRNAs in psoriasis, especially focusing on the role of lncRNAs in keratinocytes, T cells, and dendritic cells.
Increasing evidence suggests that long non-coding RNAs (lncRNAs) are of vital importance for various biological processes, and dysregulation of lncRNAs is frequently associated with various diseases such as psoriasis. LncRNAs modulate gene expression at the transcriptional, post-transcriptional, and translational levels; however, the specific regulatory mechanisms of lncRNAs in psoriasis remain largely unexplored. This review provides an overview of recent studies investigating mechanisms and functions of lncRNAs in psoriasis, especially focusing on the role of lncRNAs in keratinocytes, T cells, and dendritic cells.
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