期刊
CROHNS & COLITIS 360
卷 3, 期 1, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/crocol/otab007
关键词
ulcerative colitis; patient-reported outcome measures; Mayo Disease Activity Score; partial Mayo Score; real world
资金
- Eli Lilly and Company
Understanding ulcerative colitis disease activity assessed via different permutations of Mayo Scores can help predict endoscopic and Physician's Global Assessment scores, serving as proxies for the full Mayo Score in clinical practice/trials. This study provides insights into evaluating disease activity in patients with ulcerative colitis without the need for endoscopy or Physician's Global Assessment.
Background: Understanding ulcerative colitis disease activity assessed via the full, modified, or partial Mayo Score may help clinicians apply results from clinical trials to practice and facilitate interpretation of recent and older studies. Methods: Mayo Score variables were assessed in a cross-sectional study of 2608 ulcerative colitis patients. Results: Permutations of Mayo Scores were highly correlated, and models predicting the omitted variable from each permutation demonstrated significant agreement between predicted and observed values. Conclusions: Partial/modified Mayo Scores may be used to predict endoscopic and Physician's Global Assessment scores, and serve as proxies for the full Mayo Score in clinical practice/trials. Lay Summary Assessing disease activity in patients with ulcerative colitis can be challenging. This study shows that disease activity can sometimes be evaluated without endoscopy or Physician's Global Assessment, and helps physicians interpret results of such evaluation.
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